Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation.
Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation.
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DOI：
10.1016/j.neuropsychologia.2015.07.007
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发表时间：
2015-12
期刊：
影响因子：
2.6
通讯作者：
Boyd LA
中科院分区：
文献类型：
--
作者：
Borich MR;Brodie SM;Gray WA;Ionta S;Boyd LA
新出现的证据表明，躯体感觉功能障碍可能是与神经损伤或障碍相关的运动功能障碍的主要原因。然而，异常感觉输入和无效运动输出之间联系的神经解剖学基础仍在研究中。初级躯体感觉皮层（S1）在处理传入躯体感觉输入中起着关键作用，并有助于整合熟练运动所需的感觉和运动信号。神经成像和神经刺激方法提供了独特的机会，非侵入性研究S1的结构和功能，包括与其他皮质区域的连接。这些研究技术已经开始阐明异常S1活动和连接对神经系统患者运动功能障碍和运动功能恢复较差的偶然贡献。本文综述了最近的证据，说明S1在运动控制，运动学习和功能恢复中的作用，重点是如何利用这些调查的信息来告知中风康复，以减少运动功能障碍和改善治疗效果。
Emerging evidence indicates impairments in somatosensory function may be a major contributor to motor dysfunction associated with neurologic injury or disorders. However, the neuroanatomical substrates underlying the connection between aberrant sensory input and ineffective motor output are still under investigation. The primary somatosensory cortex (S1) plays a critical role in processing afferent somatosensory input and contributes to the integration of sensory and motor signals necessary for skilled movement. Neuroimaging and neurostimulation approaches provide unique opportunities to non-invasively study S1 structure and function including connectivity with other cortical regions. These research techniques have begun to illuminate casual contributions of abnormal S1 activity and connectivity to motor dysfunction and poorer recovery of motor function in neurologic patient populations. This review synthesizes recent evidence illustrating the role of S1 in motor control, motor learning and functional recovery with an emphasis on how information from these investigations may be exploited to inform stroke rehabilitation to reduce motor dysfunction and improve therapeutic outcomes.