An electron microscopic study on the retina of rodless mutant mice (ddN/Nagoya).
An electron microscopic study on the retina of rodless mutant mice (ddN/Nagoya).
复制标题
对无杆突变小鼠视网膜的电子显微镜研究（ddN/名古屋）。
DOI：
10.1679/aohc1950.41.427
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
H. Sakai
中科院分区：
文献类型：
--
作者：
J. Kitoh;Y. Sugiura;H. Sakai
对无杆突变小鼠（ddN/Nagoya）视网膜精细结构进行了电镜观察。这些小鼠的视网膜感光细胞在出生后发育过程中退化并完全消失。因此，在成年小鼠中，内核层与外限制膜相邻。小的三角形丛状区（外丛状层的残余）在外限制膜和双极细胞的最外排之间。这些丛状区域被突起和末端占据，分为四种类型；神经管突，神经丝状突，末端包含球形囊泡和末端包含有芯囊泡。观察到由这些结构形成的一些突触接触。神经管突的一小部分被指定为双极细胞树突，而其他剖面在本研究中无法确定。在正常小鼠视网膜内丛状层中，以带状和紧密排列的囊泡为特征的大双极终端形成双突触接触，而在突变小鼠无杆状视网膜中，较小的终端之间的双突触接触被囊泡和含带状排列的紧密排列所覆盖。在无杆视网膜的内丛状层，神经节树突、无突终末及其突触接触保存完好，但突触组成部分的大小似乎有所减少。
The fine structure of the retina in rodless mutant mice (ddN/Nagoya) was studied electron-microscopically. Photoreceptor cells of the retina in these mice degenerated and entirely disappeared in the course of postnatal development. Consequently in the adult mice the inner nuclear layer was contiguous with the outer limiting membrane. Small triangular plexiform areas (remnant of the outer plexiform layer) intervened between the outer limiting membrane and the outermost row of the bipolar cells. These plexiform areas were occupied by the processes and terminals classified into four types; neurotubular processes, neurofilamentous processes, terminals containing spherical vesicles and terminals containing cored vesicles. A few synaptic contacts made by these structures were observed. A small part of the neurotubular processes was assigned to be the bipolar cell dendrites, while the other profiles could not be identified in this study. In the inner plexiform layer of the retina in normal mice, large bipolar terminals which were characterized by the presence of ribbons and closely packed vesicles made diad synaptic contacts, whereas in the rodless retina of the mutant mice, the diad synaptic contacts between smaller terminals were observed packed less closely with vesicles and containing ribbons. In the inner plexiform layer of the rodless retina the ganglion dendrites, the amacrine terminals and their synaptic contacts were well preserved, though the size of components forming synapses seemed to be somewhat reduced.