Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas using a novel boronated porphyrin.
Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas using a novel boronated porphyrin.
复制标题
使用新型硼化卟啉光动力疗法治疗高级神经胶质瘤的 I 期和药代动力学研究。
DOI：
10.1200/jco.2001.19.2.519
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
A. Kaye
中科院分区：
文献类型：
--
作者：
M. Rosenthal;B. Kavar;J. Hill;D. Morgan;R. Nation;S. Stylli;R. Basser;S. Uren;H. Geldard;Michael D. Green;S. Kahl;A. Kaye
目的
确定用于颅内肿瘤光动力疗法 (PDT) 的新型硼化卟啉 (BOPP) 的推荐剂量、毒性特征和药代动力学。
患者和方法
对于接受术后 PDT 的颅内肿瘤患者，术前单独给予 BOPP，剂量逐渐增加（0.25、0.5、1.0、2.0、4.0 或 8.0 mg/kg），直至观察到剂量限制性毒性（DLT）。
结果
29 名可评估的颅内肿瘤患者在手术前 24 小时接受了 BOPP 静脉注射。推荐剂量为4毫克/公斤。剂量递增受到血小板减少症的限制。最常见的非血液毒性是皮肤光敏性。药代动力学参数显示，随着剂量的增加，血浆浓度-时间曲线下面积和最大浓度增加。肿瘤 BOPP 浓度也随着剂量的增加而增加。
结论
4 mg/kg 剂量的 BOPP 耐受性良好。 DLT 是血小板减少症，光敏性是唯一值得注意的其他毒性。使用 BOPP 进行 PDT 的疗效需要进一步探索。
PURPOSE
To determine the recommended dose, toxicity profile, and pharmacokinetics of a novel boronated porphyrin (BOPP) for photodynamic therapy (PDT) of intracranial tumors.
PATIENTS AND METHODS
BOPP was administered alone in increasing doses (0.25, 0.5, 1.0, 2.0, 4.0, or 8.0 mg/kg) preoperatively in patients with intracranial tumors undergoing postresection PDT until dose-limiting toxicity (DLT) was observed.
RESULTS
Twenty-nine assessable patients with intracranial tumors received BOPP intravenously 24 hours before surgery. The recommended dose was 4 mg/kg. Dose escalation was limited by thrombocytopenia. The most common nonhematologic toxicity was skin photosensitivity. Pharmacokinetic parameters showed increased area under the plasma concentration-time curve and maximum concentration with increased dose. Tumor BOPP concentrations also increased with increased dose.
CONCLUSION
BOPP at a dose of 4 mg/kg was well tolerated. DLT was thrombocytopenia, and photosensitivity was the only other toxicity of note. The efficacy of PDT using BOPP requires further exploration.
DOI：
10.1073/pnas.92.26.12126
发表时间：
1995-12-19
影响因子：
11.1
作者：
Hill, JS;Kahl, SB;Kaye, AH
通讯作者：
Kaye, AH
无胸腺裸鼠中的人神经胶质瘤异种移植物和免疫活性小鼠中的同基因卵巢癌对 nido-carboranylporphyrin 的摄取。
DOI：
10.1073/pnas.87.18.7265
发表时间：
1990
影响因子：
11.1
作者：
Kahl,SB;Joel,DD;Nawrocky,MM;Micca,PL;Tran,KP;Finkel,GC;Slatkin,DN
通讯作者：
Slatkin,DN