Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study.
Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study.
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DOI：
10.1039/c6cc06737a
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发表时间：
2016-10
影响因子：
4.9
通讯作者：
B. J. Timmer;M. A. Flos;L. M. Jørgensen;D. Proverbio;S. Altun;O. Ramström;T. Aastrup;S. Vincent
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文献类型：
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作者：
B. J. Timmer;M. A. Flos;L. M. Jørgensen;D. Proverbio;S. Altun;O. Ramström;T. Aastrup;S. Vincent
已经制备了两种基于分子博罗梅安环和十二胺笼的新型十二取代碳水化合物纳米平台，用于评估碳水化合物空间分布在其与凝集素相互作用中的重要性。使用石英晶体微天平技术表征糖纳米平台的结合亲和力，并与单价参考和十二糖基化富勒烯进行比较。
Two novel dodecasubstituted carbohydrate nanoplatforms based on molecular Borromean rings and dodecaamine cages have been prepared for use in evaluating the importance of the spatial distribution of carbohydrates in their interaction with lectins. The binding affinities of the glyconanoplatforms were characterized using quartz crystal microbalance technology and compared with a monovalent reference and dodecaglycosylated fullerenes.