Role of host age and genotype in murine enterotropic coronavirus infection.
Role of host age and genotype in murine enterotropic coronavirus infection.
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宿主年龄和基因型在鼠肠道冠状病毒感染中的作用。
DOI：
10.1007/978-1-4615-2996-5_57
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发表时间：
1993
影响因子：
--
通讯作者：
Smith,AL
中科院分区：
文献类型：
--
作者：
Barthold,SW;Smith,AL
嗜肠型小鼠肝炎病毒（MHV）可能是当代实验室小鼠群体中最常见的MHV形式，但对其发病机制知之甚少。尽管有大量关于MHV的文献，但这些报告大多与呼吸道病毒原型株有关（1，2）。当将几种原型MHV和肠嗜性MHV毒株接种到幼年小鼠中时，很明显不同的MHV毒株产生两种截然不同的疾病模式：呼吸道型，其中病毒从鼻上皮传播到多个靶器官;或肠嗜性型，其中病毒主要限于肠道，传播最小（3）。然而，肠嗜性MHV由于其挑剔和选择性的体外生长特性，其特征性很差。宿主年龄似乎显著影响嗜肠性MHV感染小鼠的疾病结局（4 - 11），宿主基因型在嗜肠性MHV疾病的易感性中也可能很重要（12）。这些都是呼吸道或多方MHV疾病发病机制中公认的因素（1，2）。本研究系统地检查了不同年龄的近交系小鼠的相对易感性，这些小鼠在经口鼻接种呼吸道MHV-JHM后，先前已显示会发生重度（BALB/cByJ）或轻度（SJL/J）疾病（13）。初步研究表明，这些小鼠基因型在感染嗜肠型MHV菌株Y时也表现出不同的疾病严重程度（12）。
Enterotropic mouse hepatitis virus (MHV) is probably the most common form of MHV in contemporary laboratory mouse populations, but very little is known about its pathogenesis. In spite of a large volume of literature on MHV, most of these reports are related to the respiratory prototype strains of virus (1, 2). When several prototype MHV and enterotropic MHV strains were inoculated into infant mice, it became clear that different MHV strains produced two distinctly different patterns of disease: respiratory, in which virus disseminated from nasal epithelium to multiple target organs; or enterotropic, in which virus was largely restricted to intestine, with minimal dissemination (3). However, enterotropic MHV has been poorly characterized because of its fastidious and selectivein vitrogrowth characteristics. Host age seems to significantly influence the outcome of disease in mice infected with enterotropic MHV (4–11), and host genotype may also be important in susceptibility to enterotropic MHV disease (12). These are well established factors in the pathogenesis of respiratory or polytropic MHV disease (1, 2). The present study systematically examined the relative susceptibility of inbred mice of different ages that have previously been shown to develop severe (BALB/cByJ) or mild (SJL/J) disease when inoculated oronasally with respiratory MHV-JHM (13). Pilot studies suggested that these mouse genotypes also display differential disease severity when infected with enterotropic MHV, strain Y (12).