THE EPIDEMIOLOGY OF PLASMODIUM-VIVAX CIRCUMSPOROZOITE PROTEIN POLYMORPHS IN THAILAND
THE EPIDEMIOLOGY OF PLASMODIUM-VIVAX CIRCUMSPOROZOITE PROTEIN POLYMORPHS IN THAILAND
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DOI：
10.4269/ajtmh.1994.50.460
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发表时间：
1994-04-01
影响因子：
3.3
通讯作者：
ROSENBERG, R
中科院分区：
文献类型：
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作者：
SUWANABUN, N;SATTABONGKOT, J;ROSENBERG, R
酶联免疫吸附测定 (ELISA) 对间日疟原虫 VK 247 和 VK 210 多晶型物的环子孢子蛋白的特征重复单元具有高度特异性，用于测试五年来在泰国四个地点的 1,711 名人类志愿者喂食蚊子产生的子孢子。除了已经描述的两种多晶型物之外，没有证据表明存在任何多晶型物。根据 ELISA，VK 247 型的总体患病率为 29.5%，包括与 VK 210 混合的那些。VK 210 和 VK 247 的相对比例在收集地点之间有所不同。在所有地方，VK 210 与 VK 247 的比率在非传播季节结束时显着高于每年季风期间的后期，这表明影响其生存的多晶型物之间可能存在内在的生物学差异。
Enzyme-linked immunosorbent assays (ELISAs) highly specific for the characteristic repeat units of the circumsporozoite proteins of the VK 247 and VK 210 polymorphs of Plasmodium vivax were used to test sporozoites produced by feeding mosquitoes on 1,711 human volunteers presenting at four locations in Thailand over five years. There was no evidence for the existence of any polymorph other than the two already described. Based on the ELISAs, the overall prevalence of the VK 247 type was 29.5%, including those found mixed with VK 210. Relative proportions of VK 210 and VK 247 differed between collection sites. At all places, the ratio of VK 210 to VK 247 was significantly higher at the end of the nontransmission season than it was later during the annual monsoon, suggesting that there may be intrinsic biological differences between the polymorphs that affect their survival.