Time trends in clinical risk stratification for prostate cancer: Implications for outcomes (data from CaPSURE)
Time trends in clinical risk stratification for prostate cancer: Implications for outcomes (data from CaPSURE)
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DOI：
10.1097/01.ju.0000095025.03331.c6
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发表时间：
2003-12-01
影响因子：
6.6
通讯作者：
Carroll, PR
中科院分区：
文献类型：
--
作者：
Cooperberg, MR;Lubeck, DP;Carroll, PR
目的：许多旨在预测前列腺癌风险的工具结合了临床 T 分期、活检格里森评分和血清前列腺特异性抗原 (PSA)。我们设计了一项研究来描述这些参数的时间趋势及其对患者风险分层的影响。材料和方法：数据摘自 CaPSURE（前列腺癌战略泌尿学研究努力），这是一个包含 8,685 名前列腺癌男性的疾病登记处。自 1989 年以来，报告了完整临床信息的 6,260 名男性被诊断出，根据 T 分期、格里森评分和 PSA 等既定参数，被分为低、中或高风险组。 结果：1989 年至 1990 年和 2001 年至 2002 年期间，患有高、中和低风险疾病的患者比例从 40.9%、28.0% 和 31.2% 变为分别为 14.8%、37.5% 和 47.7%（p
Purpose: Many instruments designed to predict prostate cancer risk use a combination of clinical T stage, biopsy Gleason score and serum prostate specific antigen (PSA). We designed a study to characterize time trends in these parameters and their impact on patient risk stratification.Materials and Methods: Data were abstracted from CaPSURE (Cancer of the Prostate Strategic Urological Research Endeavor), a disease registry of 8,685 men with prostate cancer. The 6,260 men diagnosed since 1989 who had complete clinical information reported were categorized into low, intermediate or high risk groups based on established parameters for T stage, Gleason score and PSA.Results: Between 1989 to 1990 and 2001 to 2002 the proportion of patients presenting with high, intermediate and low risk disease changed from 40.9%, 28.0% and 31.2% to 14.8%, 37.5% and 47.7%, respectively (p