Synthesis of Phenolic Glycosides: Glycosylation of Sugar Lactols with Aryl Bromides via Dual Photoredox/Ni Catalysis
Synthesis of Phenolic Glycosides: Glycosylation of Sugar Lactols with Aryl Bromides via Dual Photoredox/Ni Catalysis
复制标题
酚苷的合成：通过双光氧化还原/镍催化糖乳醇与芳基溴的糖基化
DOI：
10.1021/acs.joc.8b02129
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wen-Jing Xiao
中科院分区：
文献类型：
--
作者：
Hui Ye;Cong Xiao;Quan-Quan Zhou;Peng George Wang;Wen-Jing Xiao
Multifarious sugar lactols were efficiently transformed into the corresponding phenolic glycosides by treating with aryl bromides in acetonitrile with Ir[dF(CF3)ppy]2(dtbbpy)(PF6) as a photocatalyst under visible light irradiation. Both pyranoses and furanoses or even disaccharide could all suffer this glycosylation protocol under mild reaction conditions. A variety of phenyl glycosides can be produced in moderate to good yields (up to 93% yield), and a gram scale process of this protocol was also well-established.
