Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil.
Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil.
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DOI：
10.1016/j.expneurol.2010.09.019
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发表时间：
2011-01
影响因子：
5.3
通讯作者：
Garcia-Rill, Edgar
中科院分区：
文献类型：
--
作者：
Garrison, M. Kevin;Yates, Charlotte C.;Reese, Nancy B.;Skinner, Robert D.;Garcia-Rill, Edgar
痉挛是脊髓损伤后的常见疾病，可损害功能和生活质量。虽然许多机制被认为在痉挛中发挥作用，但运动神经元持续内向电流（PIC）的作用正在成为关键。PIC的存在可以通过对短暂传入输入的反射反应的时间总和或结束来证明。在这项研究中，结合神经生理学和新的生物力学方法被用来评估被动运动和莫达非尼管理的影响反射亢进和痉挛后，完全T-10横断大鼠。动物被分为3组（n=8），并提供每日被动自行车运动，口服莫达非尼，或没有干预。6周后，测试动物在踝关节重复背屈伸展期间的牵张反射（SR）的发条。在一组动物中测试H反射。扭矩和腓肠肌肌电图均显示仅横断组中SR卷起的证据，与两个治疗组显著不同（p<0.05）。两个治疗组的H反射频率依赖性抑郁也恢复到正常水平。这些结果为使用被动骑自行车运动和莫达非尼治疗痉挛提供了支持，并为PIC的可能贡献提供了见解。
Spasticity is a common disorder following spinal cord injury that can impair function and quality of life. While a number of mechanisms are thought to play a role in spasticity, the role of motoneuron persistent inward currents (PICs) is emerging as pivotal. The presence of PICs can be evidenced by temporal summation or wind-up of reflex responses to brief afferent inputs. In this study, a combined neurophysiological and novel biomechanical approach was used to assess the effects of passive exercise and modafinil administration on hyper-reflexia and spasticity following complete T-10 transection in the rat. Animals were divided into 3 groups (n=8) and provided daily passive cycling exercise, oral modafinil, or no intervention. After 6 weeks, animals were tested for wind-up of the stretch reflex (SR) during repeated dorsiflexion stretches of the ankle. H-reflexes were tested in a subset of animals. Both torque and gastrocnemius electromyography showed evidence of SR wind-up in the transection only group that was significantly different from both treatment groups (p<0.05). H-reflex frequency dependent depression was also restored to normal levels in both treatment groups. The results provide support for the use of passive cycling exercise and modafinil in the treatment of spasticity and provide insight into the possible contribution of PICs.
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影响因子：
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