Chromosomal assignment of the recoverin gene and cancer-associated retinopathy.
Chromosomal assignment of the recoverin gene and cancer-associated retinopathy.
复制标题
恢复基因的染色体分配和癌症相关的视网膜病变。
DOI：
10.1007/bf00364662
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Elliott,RW
中科院分区：
文献类型：
--
作者：
McGinnis,JF;Lerious,V;Pazik,J;Elliott,RW
The deduced amino acid sequence of the recently cloned mouse 23kD photoreceptor cell-specific protein showed it to be identical to the recoverin protein and the CAR (cancer-associated retinopathy) protein. DNA sequence variants were found in the mouse recoverin gene (Rcvrn), and segregation analysis of restriction fragment length variants in recombinant inbred strains of mice assignedRcvrnto mouse Chromosome (Chr) 11, betweenSparc(3.7 map units) andZfp-3(2.3 map units). These results demonstrate a close linkage of recoverin to the tumor suppressor gene,Trp53. On the basis of these data, knowledge of the function of recoverin, and the characteristics of CAR, an experimentally testable model is presented to explain the molecular basis for CAR.
