Prevalence of abnormal general movements in three-month-old infants
Prevalence of abnormal general movements in three-month-old infants
复制标题
DOI：
10.1016/j.earlhumdev.2009.01.003
复制
发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Hadders-Algra, Mijna
中科院分区：
文献类型：
--
作者：
Bouwstra, Hylco;Dijk-Stigter, Geerteke R.;Hadders-Algra, Mijna
背景：一般运动质量（GM）是衡量婴儿早期神经发育状况的敏感工具。没有信息是可用的患病率异常GM在一般population.Objective：评估异常GM在一般人群中的患病率的三个月大的婴儿和评估异常GM质量与医疗和社会风险factors.Method：我们招募了535名婴儿在6个井婴儿诊所在荷兰。GM在矫正年龄2至4个月时进行录像。GM质量由两个不了解婴儿病史的人进行评估。GM质量分为正常最佳（NO）、正常次佳（SO）、轻度异常（MA）和明确异常（DA）。只有最后一个类别意味着临床相关的功能障碍。收集社会、围产期和出生后特征，并通过单因素和Logistic回归分析评估其与DA和异常（DA + MA）GM的关系。17名婴儿（3.7%）表现为DA GM，113名（25%）表现为MA GM。DA GM与早产和孕期吸烟有关;异常（DA + MA）GM与早产、父亲职业水平相对较低和城市生活条件有关。结论：本研究表明，在一般人群中，明确异常GM的患病率为3.7%，轻度异常GM的患病率为25%。临床相关的明确异常GM与早产和妊娠期吸烟有关。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Background: The quality of general movements (GMs) is a sensitive tool to measure neurodevelopmental condition in early infancy. No information is available on prevalence rates of abnormal GMs in the general population.Objective: To assess the prevalence of abnormal GMs in the general population of three-month-old infants and to evaluate the association of abnormal GM quality with medical and social risk factors.Method: We recruited 535 infants in six well baby clinics in The Netherlands. GMs were video-taped at the corrected age of 2 to 4 months. GM-quality was assessed by two persons unaware of the infant's history. GM-quality was classified as normal optimal (NO), normal suboptimal (SO), mildly abnormal (MA) and definitely abnormal (DA). Only the last category implies clinically relevant dysfunction. Social, perinatal and postnatal characteristics were collected and their association with DA and abnormal (DA + MA) GMs were evaluated by means of univariate and logistic regression analyses.Results: GM-quality Could be assessed reliably in 455 infants (85%). Seventeen infants (3.7%) showed DA GMs and 113 (25%) MA GMs. DA GMs were associated with preterm birth and smoking during pregnancy; abnormal (DA + MA) GMs with preterm birth, a relatively low level of paternal profession and urban living conditions. These factors explained between 3% and 7% of variance.Conclusion: The study indicates that the prevalence of definitely abnormal GMs in the general population is 3.7% and that of mildly abnormal GMs 25%. The clinically relevant definitely abnormal GMs were associated with preterm birth and smoking during pregnancy. (C) 2009 Elsevier Ireland Ltd. All rights reserved.