COMMUNITY CONTROL OF ASCARIS-LUMBRICOIDES IN RURAL OYO STATE, NIGERIA - MASS, TARGETED AND SELECTIVE TREATMENT WITH LEVAMISOLE
COMMUNITY CONTROL OF ASCARIS-LUMBRICOIDES IN RURAL OYO STATE, NIGERIA - MASS, TARGETED AND SELECTIVE TREATMENT WITH LEVAMISOLE
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DOI：
10.1017/s0031182000059564
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发表时间：
1991-10-01
期刊：
影响因子：
2.4
通讯作者：
CROMPTON, DWT
中科院分区：
文献类型：
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作者：
ASAOLU, SO;HOLLAND, CV;CROMPTON, DWT
在尼日利亚奥约州农村的三个社区进行了一项研究，比较了左旋咪唑(Ketrax)集体、靶向和选择性化疗对蛔虫的控制效果。在一个村庄实施了选择性治疗，对感染最严重的20%的居民进行了治疗，在第二个村庄对2-15岁的儿童进行了针对性治疗，而在第三个村庄向所有居民提供了集体治疗，不包括1岁以下的婴儿和孕妇。如上所述，左旋咪唑的推荐剂量在1年内每隔3个月在村庄给予一次。采用改良的Kato-Katz技术，在干预前即刻和干预后3个月测定蛔虫感染率和感染强度(EPG)。在选择性治疗村，治疗前和治疗后的卵数无显著差异(平均(+/-S.D.)EPG6776+/-10791和4259+/-10909)。在靶向治疗村，仅儿童(10935+/-20094对992+/-3175)和未治疗成人(7742+/-9782对4561+/-8798)治疗前和治疗后总人口的卵子计数(9057+/-15797比2579+/-6529)有显著差异。在大规模治疗村，治疗前和治疗后的卵子计数值也有显著差异(11907+/-17220比1489+/-5165)。无论是选择性治疗、靶向治疗还是大规模治疗，干预前后村民鞭虫和钩虫感染强度均无明显变化。
A study to compare effects of mass, targeted and selective chemotherapy with levamisole (Ketrax) as an action for the control of Ascaris lumbricoides was carried out in three communities in rural Oyo State, Nigeria. Selective treatment was applied in one village by treating the most heavily infected 20 % of the inhabitants, targeted treatment in the second village involved children aged 2-15 years, while mass treatment was offered to all inhabitants excluding infants under 1 year and pregnant women in the third village. Recommended doses of levamisole were given in the villages, as described above, at 3-monthly intervals during a period of 1 year. Prevalence and intensity (epg) of A. lumbricoides infection were determined immediately before and 3 months after the period of intervention using a modified Kato-Katz technique. In the selective treatment village, no significant differences were found between the pre- and post-treatment egg counts (mean(+/- S.D.) epg 6776 +/- 10791 versus 4259 +/- 10909 respectively) of A. lumbricoides in the total population. In the targeted treatment village, significant differences were recorded in pre- and post-treatment egg counts for the total population (9057 +/- 15797 versus 2579 +/- 6529) among the children alone (10935 +/- 20094 versus 992 +/- 3175) and among the untreated adults (7742 +/- 9782 versus 4561 +/- 8798). In the mass treatment village, significant differences in pre- and post-treatment egg count values were also recorded (11907 +/- 17220 versus 1489 +/- 5165). The intensity of Trichuris trichiura and hookworm infections among the villagers before and after intervention were not observed to have changed significantly regardless of selective, targeted or mass treatment.