Early postnatal ethanol administration does not affect prepulse inhibition in rats.
Early postnatal ethanol administration does not affect prepulse inhibition in rats.
复制标题
出生后早期施用乙醇不影响大鼠的前脉冲抑制。
DOI：
10.1016/j.physbeh.2005.03.003
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Burk,JoshuaA
中科院分区：
文献类型：
--
作者：
Woolfrey,KevinM;Musisca,NicholasJ;Hunt,PamelaS;Burk,JoshuaA
人类产前乙醇暴露与相对广泛的认知缺陷，但目前尚不清楚是否一般缺陷的感官刺激的反应有助于或在信息处理的后期或更复杂的阶段的缺陷。本实验评估了大鼠出生后早期乙醇给药对前脉冲抑制的影响，在青春期（出生后第35天（PD））和成年早期（PD 70）测试动物。将动物分配至PD 4-9时通过胃内插管接受乙醇（5.25 g/kg）、假插管或未处理对照组。预暴露于乙醇没有差异影响的幅度的反应，单独的惊吓刺激，也没有影响的百分比抑制的惊吓反应的试验与前脉冲刺激。雄性大鼠表现出更大的百分比抑制比雌性大鼠PD 35在所有的刺激间隔（ISI），除了最短的，4毫秒。雌性大鼠表现出更大的百分比抑制比雄性大鼠在所有ISI PD 70。总的来说，这些数据表明，与早期暴露于乙醇相关的认知缺陷可能不归因于感觉运动门控缺陷，至少在某种程度上，这种结构是通过前脉冲抑制来测量的。
Human prenatal ethanol exposure is associated with relatively widespread cognitive deficits but it is unclear whether general deficits in responsivity to sensory stimuli contribute to or underlie the deficits in later or more complex stages of information processing. The present experiment assessed the effects of early postnatal ethanol administration in rats on prepulse inhibition, with animals tested in adolescence (postnatal day (PD) 35) and early adulthood (PD 70). Animals were assigned to receive ethanol (5.25 g/kg) via intragastric intubation on PD 4–9, sham-intubation, or to a naïve control group. Pre-exposure to ethanol did not differentially affect the magnitude of the response to the startle stimulus alone nor did it affect the percent inhibition of the startle response on trials with a prepulse stimulus. Male rats exhibited a greater percent inhibition than female rats on PD 35 at all interstimulus intervals (ISIs) except the shortest, 4 ms. Female rats exhibited a greater percent inhibition than male rats at all ISIs on PD 70. Collectively, these data demonstrate that cognitive deficits associated with early exposure to ethanol may not be attributable to deficits in sensorimotor gating, at least to the extent this construct is measured by prepulse inhibition.