Data mining for proteins characteristic of clades.
Data mining for proteins characteristic of clades.
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DOI：
10.1093/nar/gkl440
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发表时间：
2006
影响因子：
14.9
通讯作者：
Lyashenko E
中科院分区：
文献类型：
--
作者：
Bern M;Goldberg D;Lyashenko E
突触形状是一种系统发育特征，提供了共享下降的证据。随着遗传序列数据的最新扩散，分子突触形态非常重要，但是没有方便的手段来搜索它们我们已经开发了一个名为Conser的新程序，该程序可以快速组装直系同源序列，并通过各种指标进行排名，例如保护程度或与小组直系同源物的差异。进化枝。诸如嗜热菌的共生菌是否属于静脉细菌或企业的问题。
A synapomorphy is a phylogenetic character that provides evidence of shared descent. Ideally a synapomorphy is ubiquitous within the clade of related organisms and nonexistent outside the clade, implying that it arose after divergence from other extant species and before the last common ancestor of the clade. With the recent proliferation of genetic sequence data, molecular synapomorphies have assumed great importance, yet there is no convenient means to search for them over entire genomes. We have developed a new program called Conserv, which can rapidly assemble orthologous sequences and rank them by various metrics, such as degree of conservation or divergence from out-group orthologs. We have used Conserv to conduct a largescale search for molecular synapomorphies for bacterial clades. The search discovered sequences unique to clades, such as Actinobacteria, Firmicutes and γ-Proteobacteria, and shed light on several open questions, such as whether Symbiobacterium thermophilum belongs with Actinobacteria or Firmicutes. We conclude that Conserv can quickly marshall evidence relevant to evolutionary questions that would be much harder to assemble with other tools.
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影响因子：
3.4
作者：
Bloom JD;Adami C
通讯作者：
Adami C
DOI：
10.1073/pnas.90.15.7134
发表时间：
1993-08-01
影响因子：
11.1
作者：
BURKE, DH;HEARST, JE;SIDOW, A
通讯作者：
SIDOW, A
影响因子：
3.4
作者：
Fraser HB;Hirsh AE
通讯作者：
Hirsh AE
影响因子：
64.8
作者：
Hirsh, AE;Fraser, HB
通讯作者：
Fraser, HB
影响因子：
3.4
作者：
Bern, M;Goldberg, D
通讯作者：
Goldberg, D