Adiposity does not modify the effect of the dietary inflammatory potential on type 2 diabetes incidence among a prospective cohort of men.
Adiposity does not modify the effect of the dietary inflammatory potential on type 2 diabetes incidence among a prospective cohort of men.
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DOI：
10.1016/j.jnim.2019.100095
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发表时间：
2019-06-01
期刊：
影响因子：
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通讯作者：
Steck, Susan E
中科院分区：
文献类型：
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作者：
Guinter, Mark A;Merchant, Anwar T;Steck, Susan E
目的：饮食和肥胖引起的炎症反应可能与2型糖尿病（T2 DM）的发生相互作用。我们调查了肥胖改变饮食炎症潜力和2型糖尿病发病率之间关系的程度。方法：在有氧运动中心纵向研究中，使用了6,016名美国男性的数据，他们完成了3天的饮食记录。饮食炎症指数（DII）表征饮食的炎症潜力，体重指数、腰围、体脂百分比（BF）和腰围/身高比评估肥胖。在修改后的泊松回归模型中使用逆概率权重来检查肥胖是否修改了DII和T2 DM之间的关系，同时考虑了参与者的选择偏差，这些参与者失去了随访。结果：平均随访6.5年后，有336例T2 DM事件。在多变量模型中，DII评分与T2 DM发病率无显著相关性，但与最抗炎的DII四分位数相比，DII四分位数增加时点估计值持续升高。在评价BF的模型中，总体效应修正项具有显著性（p = 0.02），但进一步检查时，没有证据表明乘法和加法量表存在效应修正。影响修改不存在任何其他肥胖measurement.CONCLUSIONS：我们没有观察到证据表明，促炎饮食，如DII测量，与T2 DM的发病率，也没有证据表明，肥胖修改一个潜在的关系。需要在更大的队列中进行更长时间的随访。
PURPOSE: Inflammatory contributions from diet and adiposity may interact with respect to the development of type 2 diabetes mellitus (T2DM). We investigated the degree to which adiposity modified the association between dietary inflammatory potential and incident T2DM.METHODS: Data from 6,016 US men in the Aerobics Center Longitudinal Study who completed a 3-day diet record were used. The inflammatory potential of diet was characterized by the Dietary Inflammatory Index (DII), and adiposity was assessed with body mass index, waist circumference, body fat percentage (BF) and waist-to-height ratio. Inverse probability weights were used in modified Poisson regression models to examine whether adiposity modifies the relationship between the DII and T2DM, while accounting for selection bias from participants who were lost to follow-up.RESULTS: There were 336 incident cases of T2DM after a mean follow-up of 6.5 years. DII scores were not significantly associated with T2DM incidence in multivariable models, but point estimates were consistently elevated across increasing DII quartiles compared to the most anti-inflammatory DII quartile. In the model that evaluated BF, the term for overall effect modification was significant (p = 0.02), but there was no evidence of effect modification on the multiplicative and additive scales when examined further. Effect modification was not present for any other adiposity measures.CONCLUSIONS: We did not observe evidence that a pro-inflammatory diet, as measured by the DII, is associated with incidence of T2DM, nor evidence that adiposity modifies a potential relationship. Further investigation is needed in larger cohorts with longer follow-up.