The relationship between micronutrient status and sleep patterns: a systematic review.
The relationship between micronutrient status and sleep patterns: a systematic review.
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DOI：
10.1017/s1368980016002603
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发表时间：
2017-03
影响因子：
3.2
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Ji X;Grandner MA;Liu J
综述有关饮食和循环微量营养素与睡眠模式关系的文章，并确定与未来研究和公共卫生实践相关的问题。进行了系统审查。 PubMed、Embase 和 Scopus 的检索截止时间为 2016 年 1 月。实验性研究和观察性研究均包含在内。然而，专注于因合并症引起的继发性睡眠障碍的研究被排除在外。不同年龄段的人，从婴儿到老年人。共有二十六篇文章入选。在所审查的文章中，研究人员普遍支持微量营养素（尤其是铁和镁）在婴儿睡眠阶段的发育以及逆转老年人睡眠结构与年龄相关的变化中的潜在作用。微量营养素状况也与睡眠时间相关，睡眠时间与铁、锌和镁水平呈正相关，与铜、钾和维生素 B12 水平呈负相关。这些关系背后的机制包括微量营养素对兴奋性/抑制性神经递质和昼夜节律基因表达的影响。尽管关于微量营养素状况与睡眠之间关系的研究数量仍然很少，但已有证据表明饮食/循环微量营养素与睡眠之间存在联系。未来的研究需要调查不同人群的微量营养素水平与人类睡眠之间的剂量依赖性和纵向关系，测试微量营养素之间对睡眠结果的相互作用，并最终检查微量营养素对睡眠健康的临床相关性。
To review articles on the relationship of dietary and circulating micronutrients with sleep patterns, and to identify issues surrounding implications for future research and public health practice. A systematic review was conducted. PubMed, Embase and Scopus were searched through January 2016. Both experimental and observational studies were included. However, studies that focused on secondary sleep impairment due to comorbidities were excluded. Individuals in different age groups, from infants to older adults. A total of twenty-six articles were selected. In the articles reviewed, researchers generally supported a potential role of micronutrients, particularly Fe and Mg, in the development of sleep stages among infants and in reversing age-related alterations in sleep architecture in older adults. Micronutrient status has also been linked to sleep duration, with sleep duration positively associated with Fe, Zn and Mg levels, and negatively associated with Cu, K and vitamin B12 levels. The mechanisms underlying these relationships include the impact of micronutrients on excitatory/inhibitory neurotransmitters and the expression of circadian genes. Although the number of studies on the relationship between micronutrient status and sleep remains low, evidence has emerged that suggests a link between dietary/circulating micronutrients and sleep. Future research is needed to investigate the dose-dependent as well as the longitudinal relationships between micronutrient levels and human sleep across populations, test the interactions among micronutrients on sleep outcomes, and ultimately examine the clinical relevance of micronutrients on sleep health.