Arterial Spin Labeling (ASL) fMRI: advantages, theoretical constrains, and experimental challenges in neurosciences.
Arterial Spin Labeling (ASL) fMRI: advantages, theoretical constrains, and experimental challenges in neurosciences.
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DOI：
10.1155/2012/818456
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发表时间：
2012
影响因子：
7.6
通讯作者：
Asllani I
中科院分区：
文献类型：
--
作者：
Borogovac A;Asllani I
脑血流量(CBF)是一个公认的脑功能相关性，因此是研究正常和疾病状态下大脑的一个重要参数。动脉自旋标记(ASL)是一种无创的功能磁共振成像技术，使用动脉水作为内源性示踪剂来测量CBF。与其他技术相比，ASL提供了可靠的CBF绝对定量，具有更高的空间和时间分辨率。然而，ASL的常规应用在某种程度上受到了限制。在这篇综述中，我们首先强调ASL功能磁共振成像在基础和临床研究中的理论复杂性和技术挑战。在强调ASL相对于BOLD等其他技术的主要优势的同时，我们也阐述了ASL灌注成像的内在挑战和困惑。最后，我们阐述了该领域的几个令人兴奋的发展，我们相信这些发展将使ASL在神经科学研究中充分发挥其潜力。
Cerebral blood flow (CBF) is a well-established correlate of brain function and therefore an essential parameter for studying the brain at both normal and diseased states. Arterial spin labeling (ASL) is a noninvasive fMRI technique that uses arterial water as an endogenous tracer to measure CBF. ASL provides reliable absolute quantification of CBF with higher spatial and temporal resolution than other techniques. And yet, the routine application of ASL has been somewhat limited. In this review, we start by highlighting theoretical complexities and technical challenges of ASL fMRI for basic and clinical research. While underscoring the main advantages of ASL versus other techniques such as BOLD, we also expound on inherent challenges and confounds in ASL perfusion imaging. In closing, we expound on several exciting developments in the field that we believe will make ASL reach its full potential in neuroscience research.