Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population.
Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population.
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DOI：
10.1002/alr.22064
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发表时间：
2018-04
影响因子：
6.4
通讯作者：
Tan BK
中科院分区：
文献类型：
--
作者：
John Staniorski C;Price CPE;Weibman AR;Welch KC;Conley DB;Shintani-Smith S;Stevens WW;Peters AT;Grammer L;Lidder AK;Schleimer RP;Kern RC;Tan BK
慢性鼻窦炎（CRS）与共病哮喘密切相关。本研究使用患者报告和临床特征比较了CRS人群中早发性和迟发性哮喘。在入组临床登记研究时，CRS患者完成了22项鼻窦结局测试（SNOT-22）、哮喘控制测试（ACT）、小型哮喘生活质量问卷（miniAQLQ）、29项患者报告结局测量信息系统（PROMIS-29）和药物使用问卷。患者还报告了共病哮喘和首次哮喘诊断时的年龄。定义了早发性（<18岁）和晚发性（>18岁）哮喘组。采用方差分析（ANOVA）、卡方检验和Kruskal-Wallis检验比较患者反应。共有199名非哮喘（56.1%），71名早发性哮喘（20.0%）和85名晚发性哮喘（23.9%）CRS患者完成了调查。晚发性哮喘患者的体重指数（BMI）显著较高（p = 0.046），而年龄、性别、种族和吸烟史与哮喘发作时间无差异。SNOT-22、ACT和miniAQLQ在哮喘组之间没有差异，但晚发性哮喘患者的身体功能显著低于非哮喘患者（p = 0.008）。与非哮喘患者相比，迟发性哮喘患者鼻息肉发生率增加（p < 0.001），Lund-Mackay评分较高（p = 0.005），并接受了更多的口服类固醇疗程（p < 0.001）和内窥镜手术（p = 0.008）以治疗CRS。与早发性哮喘患者相比，晚发性哮喘患者鼻息肉（p =0.011）和CRS口服类固醇疗程（p = 0.003）增加。虽然CRS特异性和哮喘特异性患者报告结局指标（PROM）在各组之间无显著差异，但迟发性哮喘CRS患者的身体功能较差，鼻息肉更频繁，需要增加CRS治疗。迟发性哮喘可能预示CRS中更严重的疾病。
Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test (SNOT-22), Asthma Control Test (ACT), mini-Asthma Quality of Life Questionnaire (miniAQLQ), the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29), and medication use questionnaires. Patients also reported comorbid asthma and age at first asthma diagnosis. Early-onset (<18 years) and late-onset (>18 years) asthma groups were defined. Analysis of variance (ANOVA), chi-square, and Kruskal-Wallis tests were used to compare patient responses. A total of 199 non-asthmatic (56.1%), 71 early-onset asthmatic (20.0%), and 85 late-onset asthmatic (23.9%) CRS patients completed the survey. Body mass index (BMI) was significantly higher in late-onset asthmatic (p = 0.046) while age, gender, race, and smoking history did not differ with time of asthma onset. SNOT-22, ACT, and miniAQLQ were not different between asthma groups, but late-onset asthmatics had significantly lower physical function than non-asthmatics (p = 0.008). Compared to non-asthmatics, late-onset asthmatics showed increased rates of nasal polyps (p < 0.001), higher Lund-Mackay scores (p = 0.005), and had received more oral steroid courses (p < 0.001) and endoscopic surgeries (p = 0.008) for CRS management. Late-onset asthmatics compared to early-onset asthmatics showed increased nasal polyposis (p =0.011) and oral steroid courses for CRS (p = 0.003). While CRS-specific and asthma-specific patient-reported outcome measures (PROMs) were not significantly different among groups, CRS patients with late-onset asthma had poorer physical function, more frequent nasal polyposis, and required increased treatment for CRS. Late-onset asthma may predict more severe disease in CRS.
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DOI：
10.1111/cea.12472
发表时间：
2015-02
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Hulse KE;Stevens WW;Tan BK;Schleimer RP
通讯作者：
Schleimer RP
影响因子：
12.4
作者：
Hirsch AG;Stewart WF;Sundaresan AS;Young AJ;Kennedy TL;Scott Greene J;Feng W;Tan BK;Schleimer RP;Kern RC;Lidder A;Schwartz BS
通讯作者：
Schwartz BS
影响因子：
14.2
作者：
Gevaert, Philippe;Calus, Lien;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
14.2
作者：
Kelly, EAB;Busse, WW;Jarjour, NN
通讯作者：
Jarjour, NN
影响因子：
14.2
作者：
Wu, Wei;Bleecker, Eugene;Moore, Wendy;Busse, William W.;Castro, Mario;Chung, Kian Fan;Calhoun, William J.;Erzurum, Serpil;Gaston, Benjamin;Israel, Elliot;Curran-Everett, Douglas;Wenzel, Sally E.
通讯作者：
Wenzel, Sally E.