Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions
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DOI：
10.5665/sleep.5226
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发表时间：
2015-12-01
期刊：
影响因子：
5.6
通讯作者：
Wright, Kenneth P.
中科院分区：
文献类型：
--
作者：
Arble, Deanna M.;Bass, Joseph;Wright, Kenneth P.
在国家糖尿病、消化和肾脏疾病研究所举办了一个研讨会，重点是睡眠和昼夜节律紊乱对能量平衡和糖尿病的影响。讲习班确定了这一领域研究的若干关键原则和若干具体机会。睡眠/昼夜节律研究者和代谢/糖尿病研究者之间的积极合作将促进这一领域的研究。有必要将基础研究的优雅发现转化为改善美国公众的代谢健康。研究人员还需要研究人类睡眠/昼夜节律中断的影响，以超越胰岛素和葡萄糖的测量，并进行更深入的表型分析。还需要将睡眠和昼夜节律的评估以及睡眠呼吸障碍的评估纳入所有正在进行的与糖尿病风险相关的队列研究。对人类的研究需要补充以实验室为基础的模拟短睡眠和轮班工作等优雅的短期人类研究，并对患有这些疾病的普通人群进行研究。可以想象，慢性适应会发生，如果是这样的话，需要确定和理解它们发生的机制。准备翻译的特定机会领域是研究糖尿病前期和阻塞性睡眠呼吸暂停（OSA）患者的CPAP治疗是否可以预防或延迟糖尿病的发作，以及时间限制喂养是否对人类肥胖率具有与小鼠相同的影响。
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.