Bone marrow and serum concentrations of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and 1 alpha,25-dihydroxyvitamin D in patients with leukemia and normal subjects.
Bone marrow and serum concentrations of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and 1 alpha,25-dihydroxyvitamin D in patients with leukemia and normal subjects.
复制标题
白血病患者和正常受试者的骨髓和血清中 25-羟基维生素 D、24,25-二羟基维生素 D 和 1 α,25-二羟基维生素 D 的浓度。
DOI：
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发表时间：
1989
影响因子：
1.6
通讯作者：
S. Yoshida
中科院分区：
文献类型：
--
作者：
S. Masuda;T. Okano;K. Noma;M. Hamasaki;T. Kobayashi;H. Oh;S. Yoshida
测定了白血病患者和正常人的骨髓和血清中25-羟基维生素D（25-OH-D）、24,25-二羟基维生素D[24,25(OH)2D]和1α,25-二羟基维生素D[1,25(OH)2D]的浓度。各维生素 D 代谢物的骨髓和血清浓度之间存在高度显着的相关性。特别是，骨髓中 25-OH-D 和 1,25(OH)2D 的浓度与血清中的浓度非常相似。这对于控制白血病患者维生素D代谢物的骨髓水平来说是一个很大的优势，因为医生可以根据各自维生素D代谢物的血清水平计算出骨髓水平，而无需进行骨髓抽吸。当 8 名白血病患者口服 1 α-羟基维生素 D3 (1 α-OH-D3) 时，7 名患者的临床状况得到改善：4 名完全缓解 (CR)、1 名部分缓解 (PR) 和 2 名轻微缓解 (MR)，且无严重高钙血症。结果表明，1α-OH-D3 疗法对于治愈人类白血病相当有效，尽管效果并不显着。
Concentrations of 25-hydroxyvitamin D (25-OH-D), 24,25-dihydroxyvitamin D [24,25(OH)2D], and 1 alpha,25-dihydroxyvitamin D [1,25(OH)2D] in bone marrow and serum of patients with leukemia and normal subjects were assayed. There were highly significant correlations between the bone marrow and serum concentrations of the respective vitamin D metabolites. Especially, the concentrations of 25-OH-D and 1,25(OH)2D in the bone marrow gave very similar values to those in serum. This is a big advantage in controlling the bone marrow levels of vitamin D metabolites in patients with leukemia, because doctors can calculate the bone marrow levels from the serum levels of the respective vitamin D metabolites without bone marrow aspiration. When 1 alpha-hydroxyvitamin D3 (1 alpha-OH-D3) was administered orally to eight patients with leukemia, clinical conditions were improved in seven patients: four complete remissions (CR), one partial response (PR), and two minor responses (MR) without severe hypercalcemia. The results suggest that the therapy with 1 alpha-OH-D3 is fairly effective for curing human leukemia although it is not dramatic.
1,25-二羟基维生素 D3：对人白血病前期和白血病细胞的体内和体外影响。
DOI：
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发表时间：
1985
期刊：
Cancer treatment reports
影响因子：
--
作者：
Koeffler,HP;Hirji,K;Itri,L
通讯作者：
Itri,L