Natural deep eutectic characteristics of honey improve the bioactivity and safety of traditional medicines
Natural deep eutectic characteristics of honey improve the bioactivity and safety of traditional medicines
复制标题
蜂蜜的天然深共熔特性提高了传统药物的生物活性和安全性
DOI：
10.1016/j.jep.2019.112460
复制
发表时间：
2020-03-25
影响因子：
5.4
通讯作者：
Chen, Shilin
中科院分区：
文献类型：
--
作者：
Dai, Yuntao;Jin, Runa;Chen, Shilin
民族药理学意义：蜂蜜是一种具有天然深共晶溶剂(NADES)特性的重要添加剂，在传统医学中已有数千年的历史。研究目的：以黄芪为例，考察蜂蜜对黄芪的质量改善作用。材料和方法：制备生、煎、蜜炒和人工蜂蜜煎煮黄芪的汤剂，并进行细胞生物活性试验、化学成分试验、化学成分分析、细胞生物学试验、化学成分分析。结果：蜂蜜的加入提高了活性物质的浓度和口服生物利用度，保护了活性物质的乙酰化，从而提高了活性物质的生物活性。当使用纯蜂蜜时也观察到了这些变化。结论：我们的发现为蜂蜜长期以来被用作传统医药添加剂提供了潜在的解释，并使蜂蜜和蜂蜜类物质在药品生产中的应用合理化。
Ethnopharmacological relevance: Honey, an important additive with natural deep eutectic solvent (NADES) characteristics, has been used in traditional medicine for thousands of years.Aim of the study: We investigated the quality-improving effects of honey on Astragali Radix (Mikvetch Root) (RA) as an example.Materials and methods: Decoctions of raw RA, fried RA, honey-fried RA, and a man-made- honey-fried RA were prepared and compared in cell-based bioactivity tests, chemical composition tests, as well as a bioavailability test with calycosin-7-O-beta-D-glucoside.Results: The addition of honey increased the concentrations of active compounds and their oral bioavailability, provided protection against acetylation, and consequently increased their bioactivity. These changes were also observed when a pure NADES-mimicking honey was used.Conclusion: Our findings provide a potential explanation as to why honey has long been used as traditional medicine additives and rationalize the application of honey and honey-like substance in producing pharmaceuticals.