Protein synthesis in the posterior cingulate cortex in Alzheimer's disease
Protein synthesis in the posterior cingulate cortex in Alzheimer's disease
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DOI：
10.1111/j.1479-8301.2010.00350.x
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发表时间：
2011-03
期刊：
影响因子：
2
通讯作者：
Tetsuhiko Yoshida;H. Kazui;H. Tokunaga;Yumiko Kito;Yoshihiko Kubo;Nobuyo Kimura;T. Morihara;E. Shimosegawa;J. Hatazawa;M. Takeda
中科院分区：
文献类型：
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作者：
Tetsuhiko Yoshida;H. Kazui;H. Tokunaga;Yumiko Kito;Yoshihiko Kubo;Nobuyo Kimura;T. Morihara;E. Shimosegawa;J. Hatazawa;M. Takeda
背景资料：使用18 F-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）和单光子发射计算机断层扫描（SPECT）的神经影像学研究表明，后扣带回皮质（PCC）是早期阿尔茨海默病（AD）中脑代谢和灌注减少的主要和最突出区域。我们进行了目前的初步研究，以调查是否下降的脑血流量（CBF）在PCC在早期至中度AD是伴随着大脑蛋白质合成（CPS）。
Background: Neuroimaging studies using 18F‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography (FDG‐PET) and single photon emission computed tomography (SPECT) have shown that the posterior cingulate cortex (PCC) is the primary and most prominent area of cerebral metabolic and perfusional decrement in early Alzheimer's disease (AD). We carried out the present preliminary study to investigate whether a decline of cerebral blood flow (CBF) in the PCC in early to moderate AD was accompanied with that of cerebral protein synthesis (CPS).