Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer
Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer
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DOI：
10.1007/s13277-014-2630-5
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Lu, Wangkun
中科院分区：
文献类型：
--
作者：
Huang, Yufeng;Liu, Yiqian;Lu, Wangkun
组蛋白去甲基酶KDM2a已被报道在肺癌中表达失调。然而，它在胃癌中的作用仍然知之甚少。在此，我们发现KDM2A在胃癌组织中的表达水平升高。此外，KDM2A在胃癌细胞中的强制表达促进了细胞的生长和迁移，而KDM2A的下调表达则抑制了胃癌细胞的致瘤性。在机制上，KDM2A通过下调已知的胃癌进展过程中的肿瘤抑制因子--程序性细胞死亡4(PDCD4)的表达来调节胃癌细胞的生长和运动。综上所述，我们的研究表明KDM2A的上调在胃癌的发展过程中起着非常重要的作用，KDM2A可能是一个有前途的治疗靶点。
Histone demethylase KDM2A has been reported to be dysregulated in lung cancer. However, its function in gastric cancer remains poorly understood. Here, it was found that the expression level of KDM2A was increased in gastric cancer tissues. Moreover, forced expression of KDM2A in gastric cancer cells promoted cell growth and migration, while the knockdown expression of KDM2A inhibited the tumorigenicity of gastric cancer cells. Mechanistically, KDM2A regulated the growth and motility of gastric cancer cells through downregulating the expression of programmed cell death 4 (PDCD4), a known tumor suppressor in the progression of gastric cancer. Taken together, our study suggested that upregulation of KDM2A was very important in the progression of gastric cancer, and KDM2A might be a promising therapeutic target.