Strength over time of a resorbable bioscaffold for body wall repair in a dog model
Strength over time of a resorbable bioscaffold for body wall repair in a dog model
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DOI：
10.1006/jsre.2001.6176
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发表时间：
2001-08-01
影响因子：
2.2
通讯作者：
Whitson, B
中科院分区：
文献类型：
--
作者：
Badylak, S;Kokini, M;Whitson, B
在狗的体壁修复模型中，测定了一种来源于小肠粘膜下层(SIS)的生物材料的强度随时间的变化。40只犬手术造成8×12 cm的全层体壁缺损，然后用多层8层SIS修复。分别在1天、4天、7天、10天、1个月、3个月、6个月和24个月处死5只狗。在植入前和牺牲时在装置/植入部位进行球爆裂测试，以测量双轴极限承载能力。植入时该装置的强度约为73+/-12磅。植入部位的强度在10天时减少到40+/-18磅，然后逐渐增加到24个月时的156+/-26磅(P<；0.05)。可降解生物材料(如SIS)的临床应用取决于降解率和宿主重建率之间的平衡。自然产生的细胞外基质支架(如SIS)表现出快速降解，相关组织随后重塑，其强度超过用作体壁修复装置的天然组织。(C)2001年学术出版社。
The change in strength over time of a biomaterial derived from the small intestinal submucosa (SIS) was determined in a dog model of body wall repair. Full-thickness body wall defects measuring 8 x 12 cm were surgically created and then repaired with a multilaminate eight-layer form of SIS in 40 dogs. Five dogs were sacrificed at each of the following time points: 1 day, 4 days, 7 days, 10 days, and 1, 3, 6, and 24 months. Ball burst tests that measured biaxial ultimate load-bearing capability were performed on the device prior to implantation and on the device/implant site at the time of sacrifice. The strength of the device at the time of implant was approximately 73 +/- 12 pounds. The strength of the implant site diminished to 40 +/- 18 pounds at 10 days, and then progressively increased to a value of 156 +/- 26 pounds at 24 months (P < 0.05). The clinical utility of a degradable biomaterial such as SIS depends on a balance between the rate of degradation and the rate of host remodeling. Naturally occuring extracellular matrix scaffolds such as SIS show rapid degradation with associated and subsequent remodeling to a tissue with strength that exceeds that of the native tissue when used as a body wall repair device. (C) 2001 Academic Press.