Minimal Change Nephrotic Syndrome Developing during Postoperative Interferon-Beta Therapy for Malignant Melanoma
Minimal Change Nephrotic Syndrome Developing during Postoperative Interferon-Beta Therapy for Malignant Melanoma
复制标题
恶性黑色素瘤术后干扰素-β 治疗期间发生的微小病变肾病综合征
作者：
K. Nakao;H. Sugiyama;E. Makino;H. Matsuura;Akiko Ohmoto;T. Sugimoto;H. Ichikawa;J. Wada;Y. Yamasaki;H. Makino
一名64岁男性患者在恶性黑色素瘤术后接受β-干扰素治疗期间出现蛋白尿。肾脏病理结果与微小病变肾病综合征（MCNS）一致，显示内脏肾小球上皮细胞（足细胞）的广泛足突消失。停止局部注射IFN-β后，肾病范围蛋白尿逐渐消退。据我们所知，这是第一份报告，表明肾小球组织学异常与术后IFN-β治疗恶性黑色素瘤。
A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-β therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-β without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-β therapy for the malignant melanoma.