Serial Examinations of Anti-GFAP Autoantibodies in Cerebrospinal Fluids in Canine Necrotizing Meningoencephalitis
Serial Examinations of Anti-GFAP Autoantibodies in Cerebrospinal Fluids in Canine Necrotizing Meningoencephalitis
复制标题
DOI：
10.1292/jvms.71.99
复制
发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Ono, Kenichiro
中科院分区：
文献类型：
--
作者：
Matsuki, Naoaki;Takahashi, Masashi;Ono, Kenichiro
犬坏死性脑膜脑炎（NME）的特征是脑脊液（CSF）中存在抗胶质细胞酸性蛋白（GFAP）的自身抗体。为了阐明自身抗体的时程变化，对接受免疫抑制治疗的3只NME犬（2只哈巴狗和1只博美犬）进行了系列检查。哈巴狗在整个观察期（146天和813天）内保持高自身抗体滴度，并死于神经系统体征。另一方面，博美犬在第580天后从自身抗体阳性转为阴性，其NME似乎处于临床缓解状态，直至第1238天死亡。因此，即使在免疫抑制治疗期间，也可以随时间推移在犬NME中检测到抗GFAP自身抗体。然而，自身抗体也可以在发病后的一段时间内消失。
Canine necrotizing meningoencephalitis (NME) is characterized by autoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids (CSFs). To clarify the time-course changes in autoantibodies, serial examinations were conducted in three dogs with NME (two Pugs and a Pomeranian) that were treated by immunosuppressive therapy. The Pugs retained high autoantibody titers throughout the observation periods (146 and 813 days) and died with neurological signs. On the other hand, the Pomeranian switched from being positive for autoantibody to negative after day 580, and its NME seemed to be in clinical remission until death on day 1238. Therefore, the anti-GFAP autoantibodies can be detected over time in canine NME even during immunosuppressive therapies. However, the autoantibodies can also disappear within a certain period after onset.