Roles of Angiogenesis and Vascular Remodeling in Brain Vascular Malformations

Roles of Angiogenesis and Vascular Remodeling in Brain Vascular Malformations
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血管生成和血管重塑在脑血管畸形中的作用

DOI:
10.1053/j.scds.2005.01.006
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发表时间:
2004
期刊:
Seminars in Cerebrovascular Diseases and Stroke
影响因子:
--
通讯作者:
W. Young
W. Young
中科院分区:
--
文献类型:
--
作者:
T. Hashimoto;W. Young

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最近对血管生成和血管重塑的了解的进展为脑血管畸形的病理生理学提供了新的曙光,新的治疗策略正在涌现。脑血管畸形一般包括脑动静脉畸形(AVM)、海绵状畸形和硬脑膜动静脉瘘(DAVF)。尽管它们的起源还不清楚,但越来越多的证据表明,其中一些病变在成年后经历了活跃的血管生成和血管重塑。这一新概念--颅内血管畸形的主动血管生成和血管重塑--开辟了一种新的临床范式,提出了药物干预措施来稳定这些异常的血管血管,防止进一步的生长或出血。
Recent advances in understanding of angiogenesis and vascular remodeling have been shedding a new light into pathophysiology of vascular malformations in the brain, and new treatment strategies have been emerging. Generally, vascular malformations in the brain include cerebral arteriovenous malformations (AVMs), cavernous malformations, and dural arteriovenous fistulae (DAVF). Although their genesis is not well understood, there is a growing evidence suggesting that some of these lesions undergo active angiogenesis and vascular remodeling in the adult life. This new concept—active angiogenesis and vascular remodeling in intracranial vascular malformations—is opening a new clinical paradigm in which pharmacological interventions are proposed to stabilize these abnormal blood vesels and prevent further growth or hemorrhage.
DOI: 10.1161/01.cir.95.1.205
发表时间: 1997-01-07
期刊: CIRCULATION
影响因子: 37.8
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发表时间: 1998
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