Hepatitis C virus seropositivity at the time of renal transplantation in the United States: Associated factors and patient survival
Hepatitis C virus seropositivity at the time of renal transplantation in the United States: Associated factors and patient survival
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DOI：
10.1034/j.1600-6143.2001.10213.x
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发表时间：
2001-07-01
影响因子：
8.8
通讯作者：
Abbott, KC
中科院分区：
文献类型：
--
作者：
Batty, DS;Swanson, SJ;Abbott, KC
本文报道了美国肾移植数据系统中1994年7月1日至1997年6月30日期间33479例肾移植受者的历史队列分析，并对肾移植时丙型肝炎病毒（HCV）阳性的患者特征和存活率进行了统计。医学证据表也用于其他变量，但由于可用值较少，因此在单独的模型中进行分析。结果是患者的特征和生存率与HCV阳性相关。在28692名有效的HCV血清学受者中，1624名在移植时为HCV阳性（患病率为5.7%）。在逻辑回归分析中，HCV+与非裔美国人种族、男性性别、尸体供体类型、移植前透析持续时间增加、既往移植、供体HCV+、受体（但非供体）年龄、血清白蛋白、饮酒和全因住院增加相关。糖尿病和伊加肾病与HCV阳性相关性较低。总的全因未校正死亡率在HCV阳性患者中为13.1%，而在HCV阴性患者中为8.5%（p
National statistics for patient characteristics and survival of renal transplant recipients positive for hepatitis C virus (HCV+) at the time of renal transplant are presented.A historical cohort analysis of 33479 renal transplant recipients in the United States Renal Data System from I July, 1994 to 30 June, 1997 has been carried out. The medical evidence form was also used for additional variables, but because of fewer available values, this was analyzed in a separate model. Outcomes were patient characteristics and survival associated with HCV+.Of 28692 recipients with valid HCV serologies, 1624 were HCV+ at transplant (5.7% prevalence). In logistic regression analysis, HCV+ was associated with African-American race, male gender, cadaveric donor type, increased duration of pre-transplant dialysis, previous transplant, donor HCV+, recipient (but not donor) age, serum albumin, alcohol use, and increased all-cause hospitalizations. Diabetes and IgA nephropathy were less associated with HCV+. Total all-cause, unadjusted mortality was 13.1% in HCV+ vs. 8.5% in HCV- patients (p