Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study.
Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study.
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DOI：
10.1016/s0140-6736(09)60144-6
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发表时间：
2009-03-07
期刊：
影响因子：
168.9
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Chen, Jing;Gu, Dongfeng;Huang, Jianfeng;Rao, Dabeeru C.;Jaquish, Cashell E.;Hixson, James E.;Chen, Chung-Shiuan;Chen, Jichun;Lu, Fanghong;Hu, Dongsheng;Rice, Treva;Kelly, Tanika N.;Hamm, L. Lee;Whelton, Paul K.;He, Jiang
本研究旨在探讨代谢综合征与血压盐敏感性之间的关系。1，906名年龄≥16岁且无糖尿病的中国人接受了7天的低钠饮食（51.3 mmol/d），然后再接受7天的高钠饮食（307.8 mmol/d）。使用随机调零血压计在基线和每个干预期结束时测量血压。代谢综合征定义为存在≥3个风险因素：腹部肥胖、高甘油三酯、低高密度脂蛋白胆固醇、血压升高和血糖升高。多变量调整的平均变化BP（mmHg）（95%置信区间）显着更大（所有p<0.0001）与没有代谢综合征的参与者相比：-7.34（−8.21，−6.46）与−5.17（−5.51，−4.83）收缩压和−4.56（−5.28，−3.85）与−2.47（−2.74，−2.19）低钠干预期间的舒张压;在高钠干预期间，收缩压为6.51（5.76，7.26）vs 4.55（4.26，4.84），舒张压为3.25（2.56，3.94）vs 1.69（1.42，1.96）。此外，与那些没有代谢综合征风险因素的参与者相比，有4或5个代谢综合征风险因素的参与者在低钠干预期间高盐敏感性的几率增加了3.54倍（2.05，6.11），在高钠干预期间高盐敏感性的几率增加了3.13倍（1.80，5.43）。这些结果表明，代谢综合征显着增强血压对钠摄入的反应。减少钠摄入量可能是降低具有多种代谢综合征风险因素的患者血压的一个特别重要的组成部分。
We aimed to examine the association between the metabolic syndrome and salt-sensitivity of blood pressure (BP). 1,906 Chinese aged ≥16 years without diabetes were fed a low-sodium diet (51.3 mmol/day) for 7 days followed by a high-sodium diet (307.8 mmol/day) for an additional 7 days. BP were measured at baseline and at the end of each intervention period using a random-zero sphygmomanometer. Metabolic syndrome was defined as the presence of ≥3 risk factors: abdominal obesity, high triglyceride, low high-density-lipoprotein-cholesterol, elevated BP, and elevated glucose. Multivariable-adjusted mean changes (95% confidence intervals) in BP (mmHg) were significantly greater (all p<0.0001) among participants with compared to those without the metabolic syndrome: −7.34 (−8.21, −6.46) versus −5.17 (−5.51, −4.83) for systolic BP and −4.56 (−5.28, −3.85) versus −2.47 (−2.74, −2.19) for diastolic BP during the low-sodium intervention; and 6.51 (5.76, 7.26) versus 4.55 (4.26, 4.84) for systolic BP and 3.25 (2.56, 3.94) versus 1.69 (1.42, 1.96) for diastolic BP during the high-sodium intervention. In addition, compared to those with zero, participants with 4 or 5 risk factors for the metabolic syndrome had a 3.54-fold increased odds (2.05, 6.11) of high salt-sensitivity during the low-sodium intervention and a 3.13-fold increased odds (1.80, 5.43) of high salt-sensitivity during the high-sodium intervention. These results suggest that the metabolic syndrome significantly enhances BP response to sodium intake. Reduction in sodium intake may be an especially important component in reducing BP among patients with multiple risk factors for the metabolic syndrome.