Role of haem oxygenase-1 in microbial host defence.
Role of haem oxygenase-1 in microbial host defence.
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DOI：
10.1111/j.1462-5822.2008.01261.x
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发表时间：
2009-02
影响因子：
3.4
通讯作者：
Perrella MA
中科院分区：
文献类型：
--
作者：
Chung SW;Hall SR;Perrella MA
血红素氧合酶（HO）-1是一种细胞保护酶，在炎症过程中保护机体免受氧化诱导的损伤中起着关键作用。HO催化血红素降解为一氧化碳（CO）、胆绿素和亚铁。胆绿素转化为胆红素，一种有效的内源性抗氧化剂。CO具有许多生物学功能，包括抗炎特性。在各种疾病模型中，已知HO-1通过改善损伤的病理后果而发挥关键作用。在许多这些模型中，HO-1及其血红素催化剂产物的有益作用是通过抑制炎症反应。然而，当研究由微生物感染引起的疾病时，炎症反应的抑制可能会破坏免疫系统根除入侵病原体的能力。因此，关于HO-1在微生物宿主防御中的作用仍然存在问题。这篇微综述将阐述我们目前对HO-1的理解及其在各种微生物感染中的功能意义。
Heme oxygenase (HO)-1 is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. HO catalyzes the degradation of heme to carbon monoxide (CO), biliverdin, and ferrous iron. Biliverdin is converted to bilirubin, a potent endogenous antioxidant. CO has a number of biological functions, including anti-inflammatory properties. In various models of disease, HO-1 is known to play a critical role by ameliorating the pathological consequences of injury. In many of these models, the beneficial effects of HO-1 and its products of heme catabolism are by suppressing an inflammatory response. However, when investigating diseases due to microbial infections, inhibition of the inflammatory response could disrupt the ability of the immune system to eradicate an invading pathogen. Thus, questions remain regarding the role of HO-1 in microbial host defense. This microreview will address our present understanding of HO-1 and its functional significance in a variety of microbial infections.
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