Microscopic versus macroscopic diffusion in one-component fluid phase lipid bilayer membranes.
Microscopic versus macroscopic diffusion in one-component fluid phase lipid bilayer membranes.
复制标题
单组分液相脂质双层膜中的微观扩散与宏观扩散。
DOI：
10.1016/s0006-3495(91)82190-7
复制
发表时间：
1991
影响因子：
3.4
通讯作者：
Almeida,PF
中科院分区：
文献类型：
--
作者：
Vaz,WL;Almeida,PF
尊敬的先生：过去二十年来，我们用测量技术研究了膜脂在单组分La相(液体相)脂质双层膜中的横向扩散，这些技术测量：(A)使用准弹性中子散射(1，2)等方法在约两个脂类直径的距离内的极短距离扩散(1，2)；(B)使用涉及双分子反应的方法在几个脂类直径上的中程扩散(3，4)；以及(C)使用光漂白后荧光恢复方法(5)和磁共振技术(6-8)等方法在几个微米范围内的长程扩散。总体结论似乎是，由第一组技术(D_1=10~(-6)cm~2·S~(-1))和最后一组技术(D_1=10~(-6)cm~2·S~(-1))测得的平移扩散系数(D_1)之间存在大约两个数量级的差异
Dear Sir: The lateral diffusion of membrane lipids in one-component La phase (fluid phase) lipid bilayer membranes has been studied over the last twenty years by techniques that measure:(a) extreme short range diffusion over distances on the order of about two lipid diameters using methodssuch as quasielastic neutron scattering (1, 2);(b) intermediate range diffusion over several lipid diameters using methods involving bimolecular reactions (3, 4); and (c) long range diffusion over several micrometers using methods such as fluorescence recovery after photobleaching (5) and magnetic resonance techniques (6-8). The general conclusion seems to be that there is a discrepancy of about two orders of magnitude between the translational diffusion coefficients (D,) measured by the first group of techniques (D,= 10-6 cm2 s-1) and the last group (D,=