Asthma and the risk of lung cancer: a meta-analysis.
Asthma and the risk of lung cancer: a meta-analysis.
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DOI：
10.18632/oncotarget.14595
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发表时间：
2017-02-14
期刊：
影响因子：
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通讯作者：
Hou SJ
中科院分区：
文献类型：
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作者：
Qu YL;Liu J;Zhang LX;Wu CM;Chu AJ;Wen BL;Ma C;Yan XY;Zhang X;Wang DM;Lv X;Hou SJ
一些研究发现，哮喘和肺癌风险之间存在显著关联。然而，结果是不确定的。因此，我们进行了荟萃分析。我们在电子数据库中搜索所有相关文章。比值比（OR）和95%可信区间（CI）用于计算哮喘和肺癌风险之间的关联强度。哮喘与肺癌风险增加显著相关（OR = 1.44; 95% CI 1.31-1.59; P < 0.00001; I2 = 83%）。此外，不吸烟的哮喘患者患肺癌的风险也有所增加。在种族和性别的亚组分析中，高加索人、亚洲人、男性和女性哮喘患者患肺癌的风险增加。然而，哮喘与肺腺癌风险无显著相关性。在哮喘定义的分层分析中，在自我报告亚组、问卷调查亚组和登记数据库亚组中发现哮喘与肺癌之间存在显著相关性。然而，在医生诊断的哮喘亚组中没有观察到显著的相关性。总之，这项荟萃分析表明，哮喘可能与肺癌风险显著相关。
Some studies found that there was a significant association between asthma and the risk of lung cancer. However, the results are inconclusive. Therefore, we performed a meta-analysis. We searched the electronic databases for all relevant articles. Odds ratio (OR) with 95% confidence interval (CI) were used to calculate the strength of the association between asthma and lung cancer risk. Asthma was significantly associated with the increased risk of lung cancer (OR = 1.44; 95% CI 1.31–1.59; P < 0.00001; I2 = 83%). Additionally, asthma patients without smoking also had the increased lung cancer risk. In the subgroup analysis of race and gender, Caucasians, Asians, male, and female patients with asthma showed the increased risk of lung cancer. However, asthma was not significantly associated with lung adenocarcinoma risk. In the stratified analysis by asthma definition, significant associations were found between asthma and lung cancer in self-reported subgroup, questionnaire subgroup, and register databases subgroup. However, no significant association was observed in physician-diagnosed asthma subgroup. In conclusion, this meta-analysis suggested that asthma might be significantly associated with lung cancer risk.