Natural product discovery from the human microbiome.
Natural product discovery from the human microbiome.
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从人类微生物组中发现天然产物。
DOI：
10.1074/jbc.r116.762906
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Balskus,EmilyP
中科院分区：
文献类型：
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作者：
Wilson,MatthewR;Zha,Li;Balskus,EmilyP
与人类相关的微生物具有生物合成大量次生代谢物的潜力，这些次生代谢物可能介导重要的宿主-微生物和微生物-微生物相互作用。然而，目前对微生物衍生的天然产物的了解有限。各种互补的发现方法已经开始照亮这种微生物“暗物质”，这将反过来允许详细的机制研究这些分子对微生物和宿主的影响。在这里，我们回顾了最近发现微生物衍生的天然产物的努力，描述了用于识别和表征这些代谢物的关键方法，讨论了这些分子的潜在功能作用，并强调了与这一新兴研究领域相关的挑战。
Human-associated microorganisms have the potential to biosynthesize numerous secondary metabolites that may mediate important host-microbe and microbe-microbe interactions. However, there is currently a limited understanding of microbiome-derived natural products. A variety of complementary discovery approaches have begun to illuminate this microbial “dark matter,” which will in turn allow detailed mechanistic studies of the effects of these molecules on microbiome and host. Herein, we review recent efforts to uncover microbiome-derived natural products, describe the key approaches that were used to identify and characterize these metabolites, discuss potential functional roles of these molecules, and highlight challenges related to this emerging research area.