Metalloporphyrin contrast enhancement of tumors in magnetic resonance imaging. A study of human carcinoma, lymphoma, and fibrosarcoma in mice.
Metalloporphyrin contrast enhancement of tumors in magnetic resonance imaging. A study of human carcinoma, lymphoma, and fibrosarcoma in mice.
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金属卟啉在磁共振成像中增强肿瘤的对比度。
DOI：
10.1097/00004424-198710000-00009
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发表时间：
1987
影响因子：
6.7
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Ogan,MD;Revel,D;Brasch,RC
在肿瘤、淋巴瘤和肉瘤的人-鼠异种摄影模型中，研究了顺磁性金属卟啉--锰(III)-TPPS-4用于MR增强的诊断应用。15只小鼠在注射0.09 mmol/kg锰(III)TPS4前、20分钟、2、4和24小时获得自旋回波图像，每种肿瘤类型5只。所有肿瘤在平扫图像上均为均匀的中等信号强度。注射MN(III)TPS4后，所有肿瘤的信号强度均显著增强，并持续24小时。所有三种肿瘤的T1松弛时间在2-4小时达到最大值，并保持在较低的24小时。肾脏信号强度在20分钟达到最大值，并在24小时内显著高于本底水平。对于不同的肿瘤组织，Mn(III)TPS4的高弛豫度和明显的亲和力支持了这种试剂用于提高肿瘤MR成像的诊断特异性的潜在用途。
The diagnostic use of Mn (III) TPPS 4, a paramagnetic metalloporphyrin, for MR contrast enhancement was examined in humanmouse xenograph models of carcinoma, lymphoma, and sarcoma. Spin-echo images of 15 mice, five mice for each implanted tumor type, were obtained before and at 20 minutes, and 2, 4, and 24 hours following administration of 0.09 mmol/kg of Mn (III) TPPS 4. All tumors had a uniform moderate signal intensity on precontrast images. After administration of Mn (III) TPPS 4, all tumors demonstrated significant enhancement of signal intensity that persisted to 24 hours. T1 relaxation times were maximally depressed at 2-4 hours and remained low to 24 hours for all three tumors. Kidney signal intensity reached a maximum at 20 minutes and remained significantly above background for 24 hours. The high relaxivity and apparent avidity of Mn (III) TPPS 4 for divergent tumor histologies support the potential use of this agent for improved diagnostic specificity of MR imaging for neoplastic masses.