Correlates of autonomic nervous system function in a general population with special reference to HbA1c: The Nagahama study.
Correlates of autonomic nervous system function in a general population with special reference to HbA1c: The Nagahama study.
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一般人群自主神经系统功能的相关性，特别是 HbA1c：Nagahama 研究。
DOI：
10.1016/j.diabres.2020.108126
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Nakayama T; Nagahama Study Group
中科院分区：
文献类型：
--
作者：
Takahashi N;Takahashi Y;Tabara Y;Matsumoto T;Kawaguchi T;Kuriyama A;Ueshima K;Matsuda F;Chin K;Nakayama T; Nagahama Study Group
目的随着糖尿病患者糖耐量的恶化，自主神经系统（ANS）功能下降。只有少数使用血浆葡萄糖的研究报道了在包括血糖范围较大的人群中的这种关系。本研究旨在探讨ANS功能的相关因素，特别参考社区居民中比血糖更稳定的hba1c。方法利用日本长滨市7690名年龄在35-79岁的居民的1分钟心电图RR间期数据记录进行频谱分析，评估心率变异性（HRV）。对HRV参数进行对数变换。利用潜在相关因素进行多元回归分析。结果slnlf随年龄下降（回归系数为- 0.025,P < 0.001）， BMI为- 0.010，HbA1c为- 0.068,P = 0.036)。lnHF随着年龄下降(−0.029;P < 0.001),体重指数(−0.032;P < 0.001),和糖化血红蛋白(−0.173;P < 0.001)。lnLF/HF随年龄增加（0.003,P = 0.002）， BMI增加（0.023,P < 0.001）， HbA1c增加（0.105,P < 0.001）。女性lnLF和lnLF/HF均低于男性。匹兹堡睡眠质量指数评估的睡眠质量，吸烟和饮酒几乎没有关系。结论在普通居民中，年龄、BMI和hba1与副交感神经活动呈负相关，与交感神经活动呈正相关，但相关性较弱。
AimsAs the glucose tolerance of patients with diabetes worsens, autonomic nervous system (ANS) function decreases. Only a few studies, using plasma glucose, have reported on this relationship in large general populations that include people with wide range of glycemia. This study aimed to examine correlates of ANS function with special reference to HbA1cwhich is more stable than plasma glucose among community residents.MethodsSpectral analysis was performed to assess heart rate variability (HRV) using 1-minute electrocardiogram RR interval data recordings from 7690 residents aged 35–79 years in Nagahama City, Japan. HRV parameters were log-transformed. Multiple regression analysis was performed using potential correlates.ResultslnLF decreased with age (regression coefficient, −0.025; P < 0.001), BMI (−0.010; P = 0.035), and HbA1c(−0.068; P = 0.036). lnHF decreased with age (−0.029; P < 0.001), BMI (−0.032; P < 0.001), and HbA1c(−0.173; P < 0.001). lnLF/HF increased with age (0.003; P = 0.002), BMI (0.023; P < 0.001), and HbA1c(0.105; P < 0.001). Women showed lower lnLF and lnLF/HF than men. Sleep quality assessed by the Pittsburgh Sleep Quality Index, smoking and drinking had almost no relation.ConclusionsAlthough the associations were weak, age, BMI and HbA1cwere inversely correlated with parasympathetic activity, while positively correlated with sympathetic activity among general residents.