Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells
Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells
复制标题
DOI：
10.1021/jm900907s
复制
发表时间：
2009-11-12
影响因子：
7.3
通讯作者：
Recanatini, Maurizio
中科院分区：
文献类型：
--
作者：
Pizzirani, Daniela;Roberti, Marinella;Recanatini, Maurizio
为了提高结构的复杂性和多样性的现有收集的双和三联苯化合物，我们合成的混合分子，包括螺环酮（复杂轴承核心）和双/三联苯（特权片段）。化合物1、3、4和6对细胞凋亡和分化显示出明确的活性，使它们成为开发新的抗癌剂和化学探针以研究肿瘤细胞中的信号网络的潜在线索。
With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.