HYPOTHALAMIC CIRCUITS AND CIRCADIAN-RHYTHMS - EFFECTS OF KNIFE CUTS VARY WITH THEIR PLACEMENT WITHIN THE SUPRACHIASMATIC AREA
HYPOTHALAMIC CIRCUITS AND CIRCADIAN-RHYTHMS - EFFECTS OF KNIFE CUTS VARY WITH THEIR PLACEMENT WITHIN THE SUPRACHIASMATIC AREA
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DOI：
10.1016/0361-9230(86)90142-5
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发表时间：
1986-05-01
影响因子：
3.8
通讯作者：
NUNEZ, AA
中科院分区：
文献类型：
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作者：
BROWN, MH;NUNEZ, AA
下丘脑视交叉上核（SCN）及其传出投射是昼夜节律产生所必需的。为了进一步研究SCN连接在行为节律产生中的作用，对在恒定条件下饲养的完整和盲法阉割雄性大鼠进行了针对SCN背侧的水平刀切割，或假手术。自发活动和饮酒行为的节奏进行了监测，使用微型计算机。幸免于SCN的削减未能废除节奏。削减损害SCN的影响范围从周期长度的变化的节奏，废除饮酒节奏。这些和以前的结果表明，SCN和室旁核的下丘脑之间的连接是不必要的行为节律的表达。
The suprachiasmatic nucleus (SCN) of the hypothalamus and its efferent projections are necessary for the generation of circadian rhythms. To further investigate the role of SCN connections in the generation of behavior rhythms, intact and blinded-castrated male rats housed in constant conditions were given horizontal knife cuts aimed dorsal to the SCN, or sham surgery. Rhythms of locomotor activity and drinking behavior were monitored using a microcomputer. Cuts that spared the SCN failed to abolish rhythms. Effects of cuts that damaged the SCN ranged from changes in period length of the rhythms to abolition of drinking rhythms. These and previous results indicate that connections between the SCN and the paraventricular nucleus of the hypothalamus are not necessary for the expression of behavioral rhythms.