Protease Inhibitors and Experimental Acute Hemorrhagic Pancreatitis
Protease Inhibitors and Experimental Acute Hemorrhagic Pancreatitis
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蛋白酶抑制剂与实验性急性出血性胰腺炎
DOI：
10.1097/00000658-197907000-00003
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发表时间：
1979
影响因子：
9
通讯作者：
M. Steer
中科院分区：
文献类型：
--
作者：
M. Steer
据报道，蛋白水解酶抑制剂可降低某些类型的实验性胰腺炎的发病率和死亡率，尽管最近的随机试验无法证明它们在临床急性胰腺炎的治疗中有益处。我们已经评估了两种蛋白水解酶抑制剂（抑肽酶和叶绿素a）对实验性急性胰腺炎诱导的小鼠喂养胆碱缺乏的乙硫氨酸丰富的饮食的影响。抑肽酶或叶绿素a给药均未改变胰腺炎的死亡率、生化和形态学严重程度。因此，在这方面，饮食诱导的胰腺炎似乎类似于临床急性胰腺炎。缺乏有效的蛋白水解酶抑制剂治疗两种形式的胰腺炎的原因进行了讨论。
Proteolytic enzyme inhibitors have been reported to decrease morbidity and mortality from certain types of experimental pancreatitis, although recent randomized trials have been unable to demonstrate that they are of benefit in the treatment of clinical acute pancreatitis. We have evaluated the effect of two proteolytic enzyme inhibitors (trasylol and chlorophyll-a) on experimental acute pancreatitis induced in mice by the feeding of a choline-deficient ethionine-enriched diet. The mortality rate and the biochemical and morphological severity of pancreatitis were not altered by either trasylol or chlorophyll-a administration. Thus, in this respect, diet-induced pancreatitis appears to resemble clinical acute pancreatitis. The reasons for the lack of effectiveness of proteolytic enzyme inhibitors in the treatment of both forms of pancreatitis are discussed.