The kynurenine pathway in stem cell biology.
The kynurenine pathway in stem cell biology.
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DOI：
10.4137/ijtr.s12626
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发表时间：
2013-09-15
期刊：
影响因子：
--
通讯作者：
Brew BJ
中科院分区：
文献类型：
--
作者：
Jones SP;Guillemin GJ;Brew BJ
Kynurenine途径（KP）是必需氨基酸色氨酸的主要分解代谢途径。亨廷顿氏病，肌萎缩性的侧面硬化症和阿尔茨海默氏病。该评论认为，当前对KP的作用在干细胞生物学中的作用是独立的。尚未对两种相互作用进行系统的审查。证据表明KP会影响干细胞生物学并影响祖细胞的功能行为。
The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. This review considers the current understanding of the role of the KP in stem cell biology. Both of these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. A systematic review of how the two interact has not yet been conducted. Several inflammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly relevant to consider the evidence showing that the KP influences stem cell biology and impacts the functional behavior of progenitor cells.