Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature
Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature
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DOI：
10.1191/0961203302lu253oa
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发表时间：
2002-01-01
期刊：
影响因子：
2.6
通讯作者：
Drosos, AA
中科院分区：
文献类型：
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作者：
Voulgari, PV;Katsimbri, P;Drosos, AA
我们调查了性别和年龄是否影响系统性红斑狼疮（SLE）患者的临床病程和结局。因此，我们分析了489例SLE患者的临床和实验室数据，在介绍和随访期间。此外，还测量了疾病活动性评分（使用欧洲共识狼疮活动性测量，ECLAM）和器官损伤指数（使用系统性狼疮国际合作临床/美国流变学学院损伤指数，DI）。此外，还根据以下年龄组分析了两性的数据：< 55岁（年轻组）和> 55岁（老年组）。男性68人，女性421人，男女比例为1：7。我们发现男性和女性之间的平均年龄，平均诊断年龄，疾病持续时间以及随访时间没有差异。年轻男性更常出现浆膜炎和盘状病变，而女性则出现雷诺现象（RP）和颧骨皮疹。在化验结果方面，年轻女性较常出现抗Ro（SSA）和抗La（SSB）抗体，而老年女性的红细胞沉降率（ESR）水平则较高。在随访期间，男性更频繁地出现浆膜炎和肾脏疾病，而女性组更频繁地抱怨RP，光敏性和粘膜溃疡，尤其是年轻女性。贫血，白细胞减少，血小板减少和ESR水平升高也发现更频繁地在年轻女性在随访期间。然而，两个性别组之间的ECLAM和DI评分没有显著差异。使用多元Logistic回归分析，发现与年龄无关的颧骨皮疹，盘状病变，浆膜炎，RP，抗Ro（SSA）/ La（SSB）和ESR增加与性别有统计学意义的关联，而只有颧骨皮疹显示与年龄无关的性别有统计学意义的关联。因此，我们得出结论，性别影响疾病的临床表现独立于年龄，而性别和年龄不影响整体损伤评分。
We investigated whether gender and age influence the clinical course and outcome in systemic lupus erythematosus (SLE) patients. Thus, we analyzed the clinical and laboratory data of 489 SLE patients at presentation and during follow-up. In addition, disease activity score (using the European Consensus Lupus Activity Measure, ECLAM) and organ damage index (using the Systemic Lupus International Collaboration Clinics/American College of Rheumatology Damage Index, DI) were measured. Furthermore, data from both sexes were analyzed according to the following age groups: < 55 years (younger group) and > 55 years (older group). There were 68 men and 421 women, giving a ratio of 1:7. We found no differences in the mean age, mean age at diagnosis, disease duration as well as duration of follow-up between men and women. Young men presented more frequently with serositis and discoid lesions, while women presented with Raynaud's phenomenon (RP) and malar rash. Regarding the laboratory findings, young women presented more often with anti-Ro(SSA) and anti-La(SSB) antibodies, while increased levels of erythrocyte sedimentation rate (ESR) were found in old women. During follow-up, men had serositis and renal disease more frequently, while the women's group were found to complain of RP, photosensitivity and mucosal ulcers more frequently, especially in young women. Anemia, leukopenia, thrombocytopenia and elevated levels of ESR were also found more frequently in young women during follow-up. However, there were no significant differences concerning ECLAM and DI scores between the two gender groups. Using multiple logistic regression analysis, a statistically significant association of malar rash, discoid lesions, serositis, RP, anti-Ro(SSA)/ La(SSB) and increased ESR with sex was found independently of age, while only malar rash showed a statistically significant association with age independently of sex. Thus, we conclude that gender influences the clinical expression of the disease independently of age, while both gender and age do not affect the overall damage score.