Dissemination, divergence and establishment of H7N9 influenza viruses in China
Dissemination, divergence and establishment of H7N9 influenza viruses in China
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DOI：
10.1038/nature14348
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发表时间：
2015-06-04
期刊：
影响因子：
64.8
通讯作者：
Zhu, Huachen
中科院分区：
文献类型：
--
作者：
Lam, Tommy Tsan-Yuk;Zhou, Boping;Zhu, Huachen
自2013年以来，中国发生的新型H7N9禽流感病毒人类感染表明人畜共患病病原体构成的持续威胁（1，2）。虽然以中国东部为中心的第一波疫情似乎已经避免，但2013年10月再次出现人感染（参考文献3-7）。目前尚不清楚H7N9病毒是如何重新出现的，以及它将如何进一步发展;它可能成为对公共卫生的长期威胁。在这里，我们发现H7N9病毒已经从中国东部传播到南方，并在鸡中持续存在，这导致了具有不同抗性基因型的多个区域性不同谱系的建立。病毒从浙江多次传入其他省份，以及活禽市场出现H7N9病毒，加剧了人类感染的复发。H7N9病毒地理分布和遗传多样性的迅速扩大对当前的疾病控制系统构成了直接挑战。我们的研究结果还表明，H7N9病毒在中国已成为地方性流行病，并可能传播到该地区以外，遵循先前观察到的H5 N1和H9 N2流感病毒的模式（8，9）。
Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens(1,2). Although the first outbreak wave that was centred on eastern China was seemingly averted, human infections recurred in October 2013 (refs 3-7). It is unclear how the H7N9 virus re-emerged and how it will develop further; potentially it may become a long-term threat to public health. Here we show that H7N9 viruses have spread from eastern to southern China and become persistent in chickens, which has led to the establishment of multiple regionally distinct lineages with different reassortant genotypes. Repeated introductions of viruses from Zhejiang to other provinces and the presence of H7N9 viruses at live poultry markets have fuelled the recurrence of human infections. This rapid expansion of the geographical distribution and genetic diversity of the H7N9 viruses poses a direct challenge to current disease control systems. Our results also suggest that H7N9 viruses have become enzootic in China and may spread beyond the region, following the pattern previously observed with H5N1 and H9N2 influenza viruses(8,9).