The Site of Action of Desferrioxamine
The Site of Action of Desferrioxamine
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去铁胺的作用位点
DOI：
10.1111/j.1365-2141.1971.tb07051.x
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发表时间：
1971
影响因子：
6.5
通讯作者：
R. Charlton
中科院分区：
文献类型：
--
作者：
D. Lipschitz;J. Dugard;M. Simon;T. Bothwell;R. Charlton
总结。在正常大鼠中，反复注射去铁胺可显著减少肝脏和脾脏的铁储存，而在高输铁的大鼠中则没有，从而降低铁释放到血浆中的速度。这些观察结果表明，储存化合物铁蛋白和铁血黄素不是去铁胺的重要直接供体。由于血浆铁不受螯合物的结合，因此在储存库和血浆之间的通路上的某些化合物或化合物可能是主要的直接来源。通过用59Fe对肝实质细胞和网状内皮细胞中的铁进行不同标记，我们获得了去铁胺在两种细胞中螯合铁的证据。
Summary. Repeated injections of desferrioxamine significantly depleted the hepatic and splenic iron stores in normal rats, but not in rats which had been hyper‐transfused so as to reduce the rate of release of iron into the plasma. These observations indicate that the storage compounds ferritin and haemosiderin are not important direct donors of iron to desferrioxamine. Since plasma iron is not bound by the chelate, some compound or compounds on the pathway between the stores and the plasma is probably the major immediate source. By differentially labelling the iron in hepatic parenchymal cells and reticulo‐endothelial cells with 59Fe, evidence was obtained that desferrioxamine chelates iron in both cell types.