Comparison of the heparin coated vs the uncoated Jostent--no influence on restenosis or clinical outcome.
Comparison of the heparin coated vs the uncoated Jostent--no influence on restenosis or clinical outcome.
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DOI：
10.1053/euhj.2001.2608
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发表时间：
2001-10
影响因子：
39.3
通讯作者：
J. Wöhrle;E. Al-Khayer;U. Grötzinger;C. Schindler;M. Kochs;V. Hombach;M. Höher
中科院分区：
文献类型：
--
作者：
J. Wöhrle;E. Al-Khayer;U. Grötzinger;C. Schindler;M. Kochs;V. Hombach;M. Höher
目的肝素涂层支架被认为可以降低支架血栓形成和再狭窄的发生率。然而，对同一型号的涂层支架和非涂层支架进行比较的临床数据还很缺乏。我们比较了肝素涂层(C)和非涂层(U)版本的Jostent支架在6个月后的临床和血管造影结果。方法与结果277例患者306处病变行临时支架置入术，Benestent-II类病变仅40处。分娩成功率为98.4%。两组(C/U：N=156/150个病灶)在临床和操作数据上具有可比性。支架置入后，参考直径(C/U：2.68+/-0.56/2.66+/-0.53 mm)和最小管腔直径(C/U：2.48+/-0.47/2.48+/-0.52 mm)无明显差异。术后亚急性支架血栓发生率(C/U：1.9%/1.3%)和心肌梗死发生率无明显差异。术后6个月再狭窄率(79.4%)无明显差异(C/U：33.1%/30.3%)。再狭窄的危险因素为B2/C型病变(P<；0.02)、支架长度大于16 mm(P<；0.006)和支架充气压力14巴(P<；0.0063)。结论Corline肝素涂层Jostent支架对住院期间并发症发生率、支架血栓形成及再狭窄无明显影响。在每天接受临时支架治疗的患者群体中，Jostent设计提供了高的手术成功率和令人满意的6个月结果。
AIMS Heparin coating of stents is thought to reduce stent thrombosis and restenosis rates. However, clinical data comparing coated and uncoated stents of the same model are lacking. We compared the heparin coated (C) and the uncoated (U) version of the Jostent stent with regard to the clinical and angiographic outcome after 6 months. METHODS AND RESULTS Provisional stenting was done in 277 patients and 306 lesions; only 40 were Benestent-II like lesions. Delivery success rate was 98.4%. Both groups (C/U: n=156/150 lesions) were comparable in clinical and procedural data. Post stenting, reference diameter (C/U: 2.68+/-0.56/2.66+/-0.53 mm) and minimal lumen diameter did not differ (C/U: 2.48+/-0.47/2.48+/-0.52 mm). During follow-up the rate of subacute stent thrombosis (C/U: 1.9%/1.3%) and myocardial infarction did not differ. Angiography at the 6-month follow-up (79.4%) revealed no difference in restenosis rate (C/U: 33.1%/30.3%). Risk factors for restenosis were a type B2/C lesion (P<0.02), a stented segment longer than 16 mm (P<0.006) and a stent inflation pressure <14 bar (P<0.0063). CONCLUSION Corline heparin coating of the Jostent has no impact on the in-hospital complication rate, stent thrombosis or restenosis. The Jostent design gives a high procedural success rate and satisfying result at 6 months in an everyday patient population undergoing provisional stenting.