Body mass index and chronic unexplained gastrointestinal symptoms:: an adult endoscopic population based study
Body mass index and chronic unexplained gastrointestinal symptoms:: an adult endoscopic population based study
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DOI：
10.1136/gut.2004.057497
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发表时间：
2005-10-01
期刊：
影响因子：
24.5
通讯作者：
Agréus, L
中科院分区：
文献类型：
--
作者：
Aro, P;Ronkainen, J;Agréus, L
背景资料：我们的目的是确定肥胖受试者是否经历更多的胃食管反流（GORS）症状比正常受试者，并进一步确定这种关联是否被解释为食管炎或药物，降低oesophageal sphincter pressure.Methods：在一个有代表性的瑞典人口，随机样本（n = 1001，平均年龄53.5岁，51%的妇女）有上消化道内镜检查。结果：肥胖（体重指数≥ 30）的患病率为16%，肥胖组食管炎患病率（26.5%）明显高于正常组（9.3%）。肥胖与GORS之间存在相关性（比值比（OR）2.05（95%置信区间（CI）1.39，3.01）），上腹痛（OR 1.63（95% CI 1.05，2.55）），肠易激症状（OR 1.58（95% CI 1.05，2.38）），任何腹痛（OR 1.59（95% CI 1.08，2.35）），呕吐（OR 3.11（95% CI 1.18，8.20）），干呕（OR 1.74（95% CI 1.1.3，2.67）），腹泻（OR 2.2（95% CI 1.38，3.46）），任何大便急迫（OR 1.60（95% CI 1.04，2.47）），夜间尿急（OR 2.57（95% CI 1.33，4.98））和直肠排空不全（OR 1.64（95% CI 1.09，2.47）），调整年龄、性别和教育。当排除食管炎和消化性溃疡的受试者时，只有腹泻、不完全排空和呕吐与肥胖显著相关。GORS和肥胖之间的关联仍然显着调整药物的使用（OR 1.9（95%CI 1.3，3.0））。结论：GORS与肥胖有关，这似乎是解释增加上消化道内窥镜检查结果肥胖。
Background: We aimed to determine whether obese subjects experience more gastro-oesophageal reflux (GORS) symptoms than normal subjects, and further to determine if this association was explained by oesophagitis or medications that lower oesophageal sphincter pressure.Methods: In a representative Swedish population, a random sample (n = 1001, mean age 53.5 years, 51% women) had upper endoscopy. GORS was defined as any bothersome heartburn or acid regurgitation.Results: The prevalence of obesity ( body mass index >= 30) was 16%; oesophagitis was significantly more prevalent in obesity (26.5%) than in normal subjects (9.3%). There were associations between obesity and GORS ( odds ratio ( OR) 2.05 (95% confidence interval (CI) 1.39, 3.01)), epigastric pain (OR 1.63 (95% CI 1.05, 2.55)), irritable bowel symptoms (OR 1.58 ( 95% CI 1.05, 2.38)), any abdominal pain (OR 1.59 (95% CI 1.08, 2.35)), vomiting (OR 3.11 ( 95% CI 1.18, 8.20)), retching ( OR 1.74 ( 95% CI 1.1.3, 2.67)), diarrhoea ( OR 2.2 ( 95% CI 1.38, 3.46)), any stool urgency ( OR 1.60 ( 95% CI 1.04, 2.47)), nocturnal urgency ( OR 2.57 ( 95% CI 1.33, 4.98)), and incomplete rectal evacuation ( OR 1.64 ( 95% CI 1.09, 2.47)), adjusting for age, sex, and education. When subjects with oesophagitis and peptic ulcer were excluded, only diarrhoea, incomplete evacuation, and vomiting were significantly associated with obesity. The association between GORS and obesity remained significant adjusting for medication use ( OR 1.9 ( 95% CI 1.3, 3.0)).Conclusions: GORS is associated with obesity; this appears to be explained by increased upper endoscopy findings in obesity.