Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions
Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions
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DOI：
10.1016/j.jaerosci.2020.105626
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发表时间：
2021-01-01
影响因子：
4.5
通讯作者：
Feng, Yu
中科院分区：
文献类型：
--
作者：
Chen, Xiaole;Zhou, Xianguang;Feng, Yu
准确预测人体呼吸道中的飞沫传输、演变和沉积对于定量分析由于暴露于空气污染物或病毒传播而引起的健康风险至关重要。液滴/颗粒-蒸汽相互作用，即，多组分液滴/颗粒的蒸发或冷凝是需要精确建模的关键机制之一。使用经过验证的计算模型，在简化的气道几何形状中模拟了多组分液滴的传输、蒸发、吸湿生长和沉积。在气道几何形状中明确建模粘液组织层以描述粘液蒸发和热传递。与不同吸入流速相关的肺流量和气溶胶动力学模式被可视化和比较。调查的变量包括温度分布，相对湿度（RH）分布，沉积效率，液滴/颗粒分布，液滴增长率分布。数值结果表明，在计算肺气溶胶动力学研究中必须考虑液滴/颗粒与蒸汽的相互作用以及粘液组织层的传热和传质，因为它们会显着影响气溶胶传输和沉积的精确预测。此外，在这项研究中的建模框架准备扩展到预测咳嗽/打喷嚏飞沫的传输动力学开始从他们的产生和传输在室内环境中的沉积在人体呼吸系统。
Accurate predictions of the droplet transport, evolution, and deposition in human airways are critical for the quantitative analysis of the health risks due to the exposure to the airborne pollutant or virus transmission. The droplet/particle-vapor interaction, i.e., the evaporation or condensation of the multi-component droplet/particle, is one of the key mechanisms that need to be precisely modeled. Using a validated computational model, the transport, evaporation, hygroscopic growth, and deposition of multi-component droplets were simulated in a simplified airway geometry. A mucus-tissue layer is explicitly modeled in the airway geometry to describe mucus evaporation and heat transfer. Pulmonary flow and aerosol dynamics patterns associated with different inhalation flow rates are visualized and compared. Investigated variables include temperature distributions, relative humidity (RH) distributions, deposition efficiencies, droplet/particle distributions, and droplet growth ratio distributions. Numerical results indicate that the droplet/particle-vapor interaction and the heat and mass transfer of the mucus-tissue layer must be considered in the computational lung aerosol dynamics study, since they can significantly influence the precise predictions of the aerosol transport and deposition. Furthermore, the modeling framework in this study is ready to be expanded to predict transport dynamics of cough/sneeze droplets starting from their generation and transmission in the indoor environment to the deposition in the human respiratory system.