Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy
Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy
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DOI：
10.1136/bjo.86.3.311
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发表时间：
2002-03-01
影响因子：
4.1
通讯作者：
Ori, SH
中科院分区：
文献类型：
--
作者：
Funatsu, H;Yamashita, H;Ori, SH
目的：探讨玻璃体液中血管紧张素II和血管内皮生长因子（VEGF）水平与增殖性糖尿病视网膜病变（PDR）严重程度的相关性。在东京女子医科大学进行的玻璃体视网膜手术中，从51只患有PDR的糖尿病患者的眼睛，6只没有视网膜病变的糖尿病患者的眼睛，非糖尿病眼病患者16只眼（对照组）。结果：PDR患者玻璃体液中VEGF和血管紧张素II水平均显著高于非糖尿病患者和糖尿病无视网膜病变患者（均P < 0. 05），玻璃体液中VEGF和血管紧张素II水平均显著高于糖尿病无视网膜病变患者（均P < 0. 05），玻璃体液中VEGF和血管紧张素II水平均显著高于糖尿病无视网膜病变患者（均P < 0. 05）。
Aims: To investigate the correlation between the level of angiotensin II and vascular endothelial growth factor (VEGF) in the vitreous fluid and the severity of proliferative diabetic retinopathy (PDR).Methods: During vitreoretinal surgery at the Tokyo Women's Medical University, vitreous fluid samples were obtained from 51 eyes of diabetic, patients with PDR, six eyes of diabetic patients without retinopathy, and 16 eyes of non-diabetic patients with ocular disease (controls). The VEGF levels in vitreous fluid and plasma were determined by enzyme linked immunosorbent assay, while angiotensin II levels were measured by radioimmunoassay.Results: The vitreous fluid levels of VEGF and angiotensin II were significantly higher in patients with PDR than in non-diabetic patients or diabetic patients without retinopathy (all p