EFFECT OF IONIZING-RADIATION ON SYMPATHETIC-NERVE FUNCTION IN RAT PAROTID-GLANDS
EFFECT OF IONIZING-RADIATION ON SYMPATHETIC-NERVE FUNCTION IN RAT PAROTID-GLANDS
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DOI：
10.1111/j.1600-0714.1992.tb00997.x
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发表时间：
1992-03-01
影响因子：
3.3
通讯作者：
BAUM, BJ
中科院分区：
文献类型：
--
作者：
KOHN, WG;GROSSMAN, E;BAUM, BJ
电离辐射(IR)对唾液腺造成不可逆转的损害。其发病机制尚不清楚。在此之前，我们曾报道腮腺浆液性腺泡细胞可能不是IR的主要损害部位。本研究的目的是确定IR是否改变大鼠腮腺的交感神经功能。成年雄性大鼠头部和颈部接受单次剂量的照射(20Gy.IR后3d，去甲肾上腺素(NE)诱导的腮腺唾液分泌完全阻断。以[H-3]多巴胺([H-3]DA)为给药，研究照射大鼠对儿茶酚胺的摄取和代谢。60min后处死动物，摘除腮腺、颌下腺和左心室。组织中[H-3]DA和[H-3]NE的含量不受IR的影响。结果表明，IR在不影响腮腺交感神经功能的情况下，取消了腺泡对NE的反应性。
Ionizing radiation (IR) irreversibly damages salivary glands. The pathologic mechanism is unknown. Previously we reported that parotid serous acinar cells may not be the primary site of damage by IR. The purpose of this study was to determine if IR alters sympathetic nerve function in rat parotid glands. Male adult rats received a single dose of radiation (20 Gy) to the head and neck. Three days after IR, parotid saliva secretion induced by norepinephrine (NE) was completely blocked. Catecholamine uptake and metabolism were studied by injecting [H-3] dopamine ([H-3]DA) into irradiated rats, as a bolus. After 60 min, animals were sacrificed and the parotid gland, submandibular gland, and left ventricle removed. Tissue contents of [H-3]DA and [H-3]NE, identified by HPLC, were unaffected by IR. The results indicate that IR abolishes acinar responsiveness to NE without affecting parotid sympathetic nerve function.