Gray matter abnormalities in patients with narcissistic personality disorder.
Gray matter abnormalities in patients with narcissistic personality disorder.
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DOI：
10.1016/j.jpsychires.2013.05.017
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发表时间：
2013-10
影响因子：
4.8
通讯作者：
L. Schulze;I. Dziobek;A. Vater;H. Heekeren;M. Bajbouj;B. Renneberg;I. Heuser;S. Roepke
中科院分区：
文献类型：
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作者：
L. Schulze;I. Dziobek;A. Vater;H. Heekeren;M. Bajbouj;B. Renneberg;I. Heuser;S. Roepke
背景尽管自恋型人格障碍(NPD)在临床环境中的相关性，但目前还没有关于NPD的神经生物学相关性的经验数据。在本研究中，我们进行了基于体素的形态计量学分析，以提供对灰质(GM)体积局部异常的初步了解。方法从NPD患者(n=17)和年龄、性别、利手和智力匹配的健康对照组(n=17)获得脑结构图像。在全球脑组织体积和局部GM体积异常方面对两组进行比较。结果与对照组相比，NPD患者左前岛的GM体积较小。独立于组，左前脑岛的GM体积与自我报告的情感共鸣呈正相关。互补性全脑分析显示，额叶边缘区域的GM体积较小，包括嘴侧和正中扣带回皮质以及前额叶皮质的背外侧和内侧部分。结论本研究首次为NPD患者额叶边缘区域的结构异常提供了经验证据。研究结果在NPD患者情感移情能力受限的背景下进行了讨论。
BackgroundDespite the relevance of narcissistic personality disorder (NPD) in clinical settings, there is currently no empirical data available regarding the neurobiological correlates of NPD. In the present study, we performed a voxel-based morphometric analysis to provide initial insight into local abnormalities of gray matter (GM) volume.MethodsStructural brain images were obtained from patients with NPD (n= 17) and a sample of healthy controls (n= 17) matched regarding age, gender, handedness, and intelligence. Groups were compared with regard to global brain tissue volumes and local abnormalities of GM volume. Regions-of-interest analyses were calculated for the anterior insula.ResultsRelative to the control group, NPD patients had smaller GM volume in the left anterior insula. Independent of group, GM volume in the left anterior insula was positively related to self-reported emotional empathy. Complementary whole-brain analyses yielded smaller GM volume in fronto-paralimbic brain regions comprising the rostral and median cingulate cortex as well as dorsolateral and medial parts of the prefrontal cortex.ConclusionHere we provide the first empirical evidence for structural abnormalities in fronto-paralimbic brain regions of patients with NPD. The results are discussed in the context of NPD patients' restricted ability for emotional empathy.