CD62L(dim) Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer.
CD62L(dim) Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer.
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CD62Ldim 中性粒细胞特异性迁移至肺部并参与乳腺癌转移前生态位的形成
DOI：
10.3389/fonc.2020.540484
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发表时间：
2020
影响因子：
4.7
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Wang Z;Yang C;Li L;Zhang Z;Pan J;Su K;Chen W;Li J;Qiu F;Huang J
肺转移是乳腺癌患者死亡的主要原因之一。肿瘤转移的机制仍存在争议。近年来，转移前小生境的形成被认为是乳腺癌转移的关键因素，这也可以解释器官转移的倾向。我们的研究最初重新检查了小生境形成的关键时间，同时检测了一种新的中性粒细胞亚群，CD 62 Ldim中性粒细胞，这在以前的肿瘤转移中没有报道;这些细胞的数量在乳腺癌进展过程中逐渐增加，并与转移前小生境的形成密切相关。此外，我们探索了它们在肺转移前小生境中聚集的机制，发现它们被CXCL 12-CXCR 4信号通路特异性化学吸引。与CD 62 Lhi中性粒细胞相比，CD 62 Ldim中性粒细胞表现出更强的粘附性和更高的存活率。该结果为乳腺癌转移的后续靶向治疗提供了新的见解。
Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast cancer metastasis, which might also explain the tendency of organ metastasis. Our study initially re-examined the critical time of the niche formation and simultaneously detected a novel subset of neutrophils, CD62Ldim neutrophils, which had not previously been reported in tumor metastasis; the number of these cells progressively increased during breast cancer progression and was closely related to the formation of the pre-metastatic niche. Furthermore, we explored the mechanism of their aggregation in the pre-metastatic niche in the lung and found that they were specifically chemoattracted by the CXCL12-CXCR4 signaling pathway. Compared to the CD62Lhi neutrophils, CD62Ldim neutrophils exhibited stronger adhesion and increased survival. The results provide new insights into the subsequent targeted treatment of breast cancer metastasis.
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影响因子：
9.8
作者：
Gallego-Ortega D;Ledger A;Roden DL;Law AM;Magenau A;Kikhtyak Z;Cho C;Allerdice SL;Lee HJ;Valdes-Mora F;Herrmann D;Salomon R;Young AI;Lee BY;Sergio CM;Kaplan W;Piggin C;Conway JR;Rabinovich B;Millar EK;Oakes SR;Chtanova T;Swarbrick A;Naylor MJ;O'Toole S;Green AR;Timpson P;Gee JM;Ellis IO;Clark SJ;Ormandy CJ
通讯作者：
Ormandy CJ
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
50.3
作者：
Granot Z;Henke E;Comen EA;King TA;Norton L;Benezra R
通讯作者：
Benezra R
DOI：
10.1126/science.aal5081
发表时间：
2017-12-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Engblom C;Pfirschke C;Zilionis R;Da Silva Martins J;Bos SA;Courties G;Rickelt S;Severe N;Baryawno N;Faget J;Savova V;Zemmour D;Kline J;Siwicki M;Garris C;Pucci F;Liao HW;Lin YJ;Newton A;Yaghi OK;Iwamoto Y;Tricot B;Wojtkiewicz GR;Nahrendorf M;Cortez-Retamozo V;Meylan E;Hynes RO;Demay M;Klein A;Bredella MA;Scadden DT;Weissleder R;Pittet MJ
通讯作者：
Pittet MJ
影响因子：
32.4
作者：
Glodde, Nicole;Bald, Tobias;Hoelzel, Michael
通讯作者：
Hoelzel, Michael