Serum adiponectin concentrations are not related to glycosylated hemoglobin levels (HbA1c) in obese diabetic and non-diabetic Caucasians
Serum adiponectin concentrations are not related to glycosylated hemoglobin levels (HbA1c) in obese diabetic and non-diabetic Caucasians
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DOI：
10.1055/s-2007-992116
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发表时间：
2008-03-01
影响因子：
1.8
通讯作者：
Sowifiski, J.
中科院分区：
文献类型：
--
作者：
Owecki, M.;Miczke, A.;Sowifiski, J.
尽管循环脂联素与人类肥胖、2型糖尿病和血清糖化血红蛋白(HbA1c)呈负相关，但在这一问题上存在相互矛盾的报告。在这项研究中，测量了肥胖的非糖尿病人和糖尿病人的血清脂联素浓度，以检查它们是否与HbA1c水平有关。研究采用世界卫生组织对肥胖和糖尿病的定义。对105例正常血糖肥胖受试者和49例肥胖糖尿病患者(年龄分别为51±6.9岁和52±6.7岁)进行了研究。测量体重指数、糖化血红蛋白和体脂百分比。脂联素的测定采用酶联免疫吸附试验。糖尿病患者与非糖尿病患者的血清脂联素浓度虽有差异，但与糖化血红蛋白无相关性(r=-0.0814；P=0.5823，r=-0)。186 1；P=0。1099，分别用于糖尿病患者和非糖尿病患者)。糖尿病患者和非糖尿病患者根据他们的HbA1c水平被分成三组。高糖化血红蛋白(H)、中等糖化血红蛋白(1)和低糖化血红蛋白(L)患者的血浆脂联素水平无显著差异。
Although circulating adiponectin has been inversely correlated with obesity, type 2 diabetes and serum glycosylated hemoglobin (HbA1c) in humans, contradictory reports on that subject exist. In this study, serum concentrations of adiponectin in obese non-diabetic and diabetic humans were measured to examine whether they were associated with levels of HbA1c. The WHO definitions of obesity and diabetes were used. One hundred and five obese euglycemic subjects and 49 obese diabetics (aged 51 +/- 6.9, and 52 +/- 6.7 years, respectively) were studied. Their BMI, HbA1c and % of body fat were measured. Adiponectin was determined by an enzyme-linked immunosorbent assay. Although the serum adiponectin concentrations differed between diabetics and non-diabetics (P < 0.01), they were not correlated with HbA1c (r = - 0.0814; P = 0.5823, and r = - 0. 186 1; P = 0. 1099, for diabetics and non-diabetics, respectively). Both diabetics and non-diabetics were segregated into tertiles according to their HbA1c levels. Plasma adiponectin did not differ significantly between the high (H), intermediate (1), and low (L) HbA1c tertiles.